Inclusive Polygenic Scores (iPGS)

Overview

Admixed individuals offer unique opportunities to address limited transferability in polygenic scores (PGS), given the substantial trans-ancestry genetic correlation in many complex traits. However, they are rarely considered in PGS training, given the challenges in representing ancestry-matched linkage-disequilibrium reference panels for admixed individuals. We developed inclusive PGS (iPGS), a PGS training strategy to capture ancestry-shared genetic effects by finding the exact solution for penalized regression on individual-level data, thus naturally applicable to admixed individuals.

/static/data/figures/TanigawaKellis2023_graphical_abstract_web.png

We host the results from the following studies. You may learn more about our iPGS browser here.


News


References