Power of Inclusion: enhancing polygenic prediction with admixed individuals

Tanigawa and Kellis. Am J Hum Genet. (2023).


Predictive performance

We performed a systematic predictive performance evaluation of inclusive PGS (iPGS) models and PRS-CSx across 60 anthropometric and hematological traits in UK Biobank.

Anthropometric traits

/static/data/tanigawakellis2023/Figure_S4A_web.png

Hematological traits

/static/data/tanigawakellis2023/Figure_S4B_web.png

The predictive performance (R2) in white British (WB), non-British white (NBW), South Asian (SA), African (Afr), and the other population group (Others) in UK Biobank are shown for six select models for comparison: (i) WB-only, (ii) inclusive, (iii) inclusive-FixN, (iv) Multi-pop, NoAdmixed, (vii) PRS-CSx, and (viii) PRS-CSx (N=256k). In the browser, we show the results for the inclusive model (model ii).


Predictive performance of inclusive PGS model

Trait category Trait Population Model Metric Predictive Performance 95% CI P-value
Trait category Trait Population Model Metric Predictive Performance 95% CI P-value
AnthropometrySitting heightwhite BritishCovariate-only modelR20.435[0.430, 0.441]<1.0x10-300
AnthropometrySitting heightwhite BritishGenotype-only modelR20.133[0.129, 0.138]<1.0x10-300
AnthropometrySitting heightwhite BritishFull model (covariates and genotypes)R20.567[0.562, 0.572]<1.0x10-300
AnthropometrySitting heightNon-British whiteCovariate-only modelR20.435[0.408, 0.462]<1.0x10-300
AnthropometrySitting heightNon-British whiteGenotype-only modelR20.148[0.124, 0.172]1.7x10-102
AnthropometrySitting heightNon-British whiteFull model (covariates and genotypes)R20.563[0.539, 0.587]<1.0x10-300
AnthropometrySitting heightSouth AsianCovariate-only modelR20.426[0.388, 0.464]1.2x10-176
AnthropometrySitting heightSouth AsianGenotype-only modelR20.068[0.043, 0.093]5.6x10-24
AnthropometrySitting heightSouth AsianFull model (covariates and genotypes)R20.477[0.440, 0.513]2.3x10-205
AnthropometrySitting heightAfricanCovariate-only modelR20.356[0.312, 0.399]2.9x10-115
AnthropometrySitting heightAfricanGenotype-only modelR20.019[0.004, 0.034]2.1x10-06
AnthropometrySitting heightAfricanFull model (covariates and genotypes)R20.362[0.319, 0.405]8.3x10-118
AnthropometrySitting heightOthersCovariate-only modelR20.457[0.441, 0.473]<1.0x10-300
AnthropometrySitting heightOthersGenotype-only modelR20.146[0.132, 0.160]1.0x10-275
AnthropometrySitting heightOthersFull model (covariates and genotypes)R20.563[0.548, 0.577]<1.0x10-300
AnthropometryBMIwhite BritishCovariate-only modelR20.018[0.016, 0.020]9.8x10-273
AnthropometryBMIwhite BritishGenotype-only modelR20.119[0.114, 0.124]<1.0x10-300
AnthropometryBMIwhite BritishFull model (covariates and genotypes)R20.134[0.129, 0.139]<1.0x10-300
AnthropometryBMINon-British whiteCovariate-only modelR20.019[0.009, 0.029]1.2x10-13
AnthropometryBMINon-British whiteGenotype-only modelR20.112[0.090, 0.133]6.4x10-76
AnthropometryBMINon-British whiteFull model (covariates and genotypes)R20.124[0.102, 0.147]9.1x10-85
AnthropometryBMISouth AsianCovariate-only modelR20.002[-0.003, 0.007]6.8x10-02
AnthropometryBMISouth AsianGenotype-only modelR20.089[0.062, 0.117]2.7x10-31
AnthropometryBMISouth AsianFull model (covariates and genotypes)R20.083[0.056, 0.110]5.1x10-29
AnthropometryBMIAfricanCovariate-only modelR20.002[-0.003, 0.007]1.4x10-01
AnthropometryBMIAfricanGenotype-only modelR20.018[0.003, 0.032]4.3x10-06
AnthropometryBMIAfricanFull model (covariates and genotypes)R20.009[-0.001, 0.020]9.1x10-04
AnthropometryBMIOthersCovariate-only modelR20.050[0.040, 0.059]3.3x10-90
AnthropometryBMIOthersGenotype-only modelR20.103[0.090, 0.115]9.1x10-190
AnthropometryBMIOthersFull model (covariates and genotypes)R20.137[0.123, 0.151]8.0x10-256
AnthropometryWeightwhite BritishCovariate-only modelR20.218[0.213, 0.224]<1.0x10-300
AnthropometryWeightwhite BritishGenotype-only modelR20.111[0.107, 0.116]<1.0x10-300
AnthropometryWeightwhite BritishFull model (covariates and genotypes)R20.328[0.322, 0.333]<1.0x10-300
AnthropometryWeightNon-British whiteCovariate-only modelR20.235[0.208, 0.262]4.2x10-169
AnthropometryWeightNon-British whiteGenotype-only modelR20.120[0.098, 0.143]3.6x10-82
AnthropometryWeightNon-British whiteFull model (covariates and genotypes)R20.346[0.318, 0.374]5.3x10-267
AnthropometryWeightSouth AsianCovariate-only modelR20.153[0.120, 0.187]4.4x10-55
AnthropometryWeightSouth AsianGenotype-only modelR20.096[0.068, 0.124]3.8x10-34
AnthropometryWeightSouth AsianFull model (covariates and genotypes)R20.253[0.215, 0.291]4.5x10-95
AnthropometryWeightAfricanCovariate-only modelR20.026[0.008, 0.043]2.4x10-08
AnthropometryWeightAfricanGenotype-only modelR20.019[0.004, 0.034]2.1x10-06
AnthropometryWeightAfricanFull model (covariates and genotypes)R20.043[0.021, 0.065]4.3x10-13
AnthropometryWeightOthersCovariate-only modelR20.263[0.246, 0.280]<1.0x10-300
AnthropometryWeightOthersGenotype-only modelR20.102[0.090, 0.115]1.2x10-188
AnthropometryWeightOthersFull model (covariates and genotypes)R20.343[0.326, 0.360]<1.0x10-300
AnthropometryBody fat %white BritishCovariate-only modelR20.460[0.454, 0.465]<1.0x10-300
AnthropometryBody fat %white BritishGenotype-only modelR20.056[0.053, 0.059]<1.0x10-300
AnthropometryBody fat %white BritishFull model (covariates and genotypes)R20.517[0.512, 0.523]<1.0x10-300
AnthropometryBody fat %Non-British whiteCovariate-only modelR20.424[0.397, 0.451]<1.0x10-300
AnthropometryBody fat %Non-British whiteGenotype-only modelR20.060[0.044, 0.077]3.0x10-40
AnthropometryBody fat %Non-British whiteFull model (covariates and genotypes)R20.491[0.465, 0.517]<1.0x10-300
AnthropometryBody fat %South AsianCovariate-only modelR20.572[0.540, 0.605]5.5x10-270
AnthropometryBody fat %South AsianGenotype-only modelR20.046[0.025, 0.067]1.4x10-16
AnthropometryBody fat %South AsianFull model (covariates and genotypes)R20.604[0.573, 0.635]5.8x10-294
AnthropometryBody fat %AfricanCovariate-only modelR20.610[0.575, 0.644]9.3x10-240
AnthropometryBody fat %AfricanGenotype-only modelR20.010[-0.001, 0.021]7.4x10-04
AnthropometryBody fat %AfricanFull model (covariates and genotypes)R20.594[0.559, 0.630]3.4x10-230
AnthropometryBody fat %OthersCovariate-only modelR20.431[0.414, 0.447]<1.0x10-300
AnthropometryBody fat %OthersGenotype-only modelR20.059[0.049, 0.069]7.9x10-106
AnthropometryBody fat %OthersFull model (covariates and genotypes)R20.476[0.460, 0.492]<1.0x10-300
AnthropometryWhole body fat masswhite BritishCovariate-only modelR20.068[0.065, 0.072]<1.0x10-300
AnthropometryWhole body fat masswhite BritishGenotype-only modelR20.105[0.100, 0.109]<1.0x10-300
AnthropometryWhole body fat masswhite BritishFull model (covariates and genotypes)R20.172[0.167, 0.178]<1.0x10-300
AnthropometryWhole body fat massNon-British whiteCovariate-only modelR20.044[0.030, 0.059]9.5x10-30
AnthropometryWhole body fat massNon-British whiteGenotype-only modelR20.115[0.093, 0.136]6.2x10-77
AnthropometryWhole body fat massNon-British whiteFull model (covariates and genotypes)R20.159[0.135, 0.183]1.7x10-108
AnthropometryWhole body fat massSouth AsianCovariate-only modelR20.135[0.103, 0.168]1.1x10-47
AnthropometryWhole body fat massSouth AsianGenotype-only modelR20.098[0.069, 0.126]3.3x10-34
AnthropometryWhole body fat massSouth AsianFull model (covariates and genotypes)R20.213[0.176, 0.249]3.4x10-77
AnthropometryWhole body fat massAfricanCovariate-only modelR20.205[0.164, 0.245]1.0x10-59
AnthropometryWhole body fat massAfricanGenotype-only modelR20.013[0.000, 0.026]9.8x10-05
AnthropometryWhole body fat massAfricanFull model (covariates and genotypes)R20.157[0.119, 0.194]5.7x10-45
AnthropometryWhole body fat massOthersCovariate-only modelR20.092[0.080, 0.104]6.3x10-166
AnthropometryWhole body fat massOthersGenotype-only modelR20.101[0.088, 0.113]2.4x10-182
AnthropometryWhole body fat massOthersFull model (covariates and genotypes)R20.174[0.159, 0.189]<1.0x10-300
AnthropometryWhole body fat-free masswhite BritishCovariate-only modelR20.709[0.706, 0.713]<1.0x10-300
AnthropometryWhole body fat-free masswhite BritishGenotype-only modelR20.053[0.050, 0.057]<1.0x10-300
AnthropometryWhole body fat-free masswhite BritishFull model (covariates and genotypes)R20.763[0.760, 0.766]<1.0x10-300
AnthropometryWhole body fat-free massNon-British whiteCovariate-only modelR20.706[0.688, 0.724]<1.0x10-300
AnthropometryWhole body fat-free massNon-British whiteGenotype-only modelR20.063[0.046, 0.080]7.8x10-42
AnthropometryWhole body fat-free massNon-British whiteFull model (covariates and genotypes)R20.763[0.747, 0.778]<1.0x10-300
AnthropometryWhole body fat-free massSouth AsianCovariate-only modelR20.650[0.622, 0.679]<1.0x10-300
AnthropometryWhole body fat-free massSouth AsianGenotype-only modelR20.030[0.013, 0.046]4.1x10-11
AnthropometryWhole body fat-free massSouth AsianFull model (covariates and genotypes)R20.695[0.669, 0.721]<1.0x10-300
AnthropometryWhole body fat-free massAfricanCovariate-only modelR20.583[0.548, 0.619]1.6x10-223
AnthropometryWhole body fat-free massAfricanGenotype-only modelR20.007[-0.002, 0.016]4.3x10-03
AnthropometryWhole body fat-free massAfricanFull model (covariates and genotypes)R20.585[0.550, 0.621]1.0x10-224
AnthropometryWhole body fat-free massOthersCovariate-only modelR20.711[0.700, 0.722]<1.0x10-300
AnthropometryWhole body fat-free massOthersGenotype-only modelR20.040[0.031, 0.048]5.9x10-71
AnthropometryWhole body fat-free massOthersFull model (covariates and genotypes)R20.751[0.741, 0.760]<1.0x10-300
AnthropometryWhole body water masswhite BritishCovariate-only modelR20.706[0.702, 0.710]<1.0x10-300
AnthropometryWhole body water masswhite BritishGenotype-only modelR20.054[0.050, 0.057]<1.0x10-300
AnthropometryWhole body water masswhite BritishFull model (covariates and genotypes)R20.760[0.757, 0.763]<1.0x10-300
AnthropometryWhole body water massNon-British whiteCovariate-only modelR20.700[0.682, 0.718]<1.0x10-300
AnthropometryWhole body water massNon-British whiteGenotype-only modelR20.066[0.048, 0.083]6.3x10-44
AnthropometryWhole body water massNon-British whiteFull model (covariates and genotypes)R20.758[0.743, 0.773]<1.0x10-300
AnthropometryWhole body water massSouth AsianCovariate-only modelR20.648[0.620, 0.677]<1.0x10-300
AnthropometryWhole body water massSouth AsianGenotype-only modelR20.030[0.013, 0.047]3.5x10-11
AnthropometryWhole body water massSouth AsianFull model (covariates and genotypes)R20.693[0.667, 0.719]<1.0x10-300
AnthropometryWhole body water massAfricanCovariate-only modelR20.581[0.545, 0.617]3.2x10-222
AnthropometryWhole body water massAfricanGenotype-only modelR20.008[-0.002, 0.018]2.3x10-03
AnthropometryWhole body water massAfricanFull model (covariates and genotypes)R20.584[0.548, 0.619]8.9x10-224
AnthropometryWhole body water massOthersCovariate-only modelR20.709[0.699, 0.720]<1.0x10-300
AnthropometryWhole body water massOthersGenotype-only modelR20.039[0.031, 0.048]1.5x10-70
AnthropometryWhole body water massOthersFull model (covariates and genotypes)R20.749[0.739, 0.758]<1.0x10-300
AnthropometryBasal metabolic ratewhite BritishCovariate-only modelR20.630[0.625, 0.634]<1.0x10-300
AnthropometryBasal metabolic ratewhite BritishGenotype-only modelR20.063[0.059, 0.067]<1.0x10-300
AnthropometryBasal metabolic ratewhite BritishFull model (covariates and genotypes)R20.693[0.689, 0.697]<1.0x10-300
AnthropometryBasal metabolic rateNon-British whiteCovariate-only modelR20.623[0.602, 0.645]<1.0x10-300
AnthropometryBasal metabolic rateNon-British whiteGenotype-only modelR20.076[0.058, 0.095]5.9x10-51
AnthropometryBasal metabolic rateNon-British whiteFull model (covariates and genotypes)R20.691[0.672, 0.710]<1.0x10-300
AnthropometryBasal metabolic rateSouth AsianCovariate-only modelR20.561[0.527, 0.594]7.8x10-262
AnthropometryBasal metabolic rateSouth AsianGenotype-only modelR20.039[0.020, 0.058]3.3x10-14
AnthropometryBasal metabolic rateSouth AsianFull model (covariates and genotypes)R20.614[0.583, 0.645]1.1x10-302
AnthropometryBasal metabolic rateAfricanCovariate-only modelR20.466[0.425, 0.507]8.4x10-161
AnthropometryBasal metabolic rateAfricanGenotype-only modelR20.009[-0.002, 0.019]1.3x10-03
AnthropometryBasal metabolic rateAfricanFull model (covariates and genotypes)R20.470[0.429, 0.511]9.8x10-163
AnthropometryBasal metabolic rateOthersCovariate-only modelR20.636[0.623, 0.648]<1.0x10-300
AnthropometryBasal metabolic rateOthersGenotype-only modelR20.051[0.042, 0.060]2.0x10-91
AnthropometryBasal metabolic rateOthersFull model (covariates and genotypes)R20.682[0.671, 0.694]<1.0x10-300
AnthropometryImpd. of whole bodywhite BritishCovariate-only modelR20.439[0.433, 0.444]<1.0x10-300
AnthropometryImpd. of whole bodywhite BritishGenotype-only modelR20.085[0.081, 0.089]<1.0x10-300
AnthropometryImpd. of whole bodywhite BritishFull model (covariates and genotypes)R20.522[0.517, 0.528]<1.0x10-300
AnthropometryImpd. of whole bodyNon-British whiteCovariate-only modelR20.426[0.399, 0.453]<1.0x10-300
AnthropometryImpd. of whole bodyNon-British whiteGenotype-only modelR20.082[0.063, 0.101]1.3x10-54
AnthropometryImpd. of whole bodyNon-British whiteFull model (covariates and genotypes)R20.507[0.481, 0.532]<1.0x10-300
AnthropometryImpd. of whole bodySouth AsianCovariate-only modelR20.360[0.321, 0.399]8.4x10-143
AnthropometryImpd. of whole bodySouth AsianGenotype-only modelR20.056[0.033, 0.078]6.9x10-20
AnthropometryImpd. of whole bodySouth AsianFull model (covariates and genotypes)R20.417[0.379, 0.456]1.0x10-172
AnthropometryImpd. of whole bodyAfricanCovariate-only modelR20.254[0.212, 0.297]3.1x10-76
AnthropometryImpd. of whole bodyAfricanGenotype-only modelR20.027[0.009, 0.045]1.7x10-08
AnthropometryImpd. of whole bodyAfricanFull model (covariates and genotypes)R20.279[0.236, 0.322]8.0x10-85
AnthropometryImpd. of whole bodyOthersCovariate-only modelR20.441[0.425, 0.458]<1.0x10-300
AnthropometryImpd. of whole bodyOthersGenotype-only modelR20.053[0.043, 0.063]9.6x10-95
AnthropometryImpd. of whole bodyOthersFull model (covariates and genotypes)R20.492[0.477, 0.508]<1.0x10-300
AnthropometryImpd. of leg Rwhite BritishCovariate-only modelR20.193[0.188, 0.198]<1.0x10-300
AnthropometryImpd. of leg Rwhite BritishGenotype-only modelR20.111[0.107, 0.116]<1.0x10-300
AnthropometryImpd. of leg Rwhite BritishFull model (covariates and genotypes)R20.303[0.297, 0.309]<1.0x10-300
AnthropometryImpd. of leg RNon-British whiteCovariate-only modelR20.189[0.164, 0.215]3.3x10-131
AnthropometryImpd. of leg RNon-British whiteGenotype-only modelR20.105[0.084, 0.127]1.2x10-70
AnthropometryImpd. of leg RNon-British whiteFull model (covariates and genotypes)R20.297[0.269, 0.325]3.5x10-219
AnthropometryImpd. of leg RSouth AsianCovariate-only modelR20.113[0.083, 0.143]1.1x10-39
AnthropometryImpd. of leg RSouth AsianGenotype-only modelR20.074[0.048, 0.099]4.9x10-26
AnthropometryImpd. of leg RSouth AsianFull model (covariates and genotypes)R20.186[0.150, 0.221]8.4x10-67
AnthropometryImpd. of leg RAfricanCovariate-only modelR20.056[0.031, 0.081]3.1x10-16
AnthropometryImpd. of leg RAfricanGenotype-only modelR20.018[0.003, 0.032]5.3x10-06
AnthropometryImpd. of leg RAfricanFull model (covariates and genotypes)R20.073[0.045, 0.101]6.2x10-21
AnthropometryImpd. of leg ROthersCovariate-only modelR20.212[0.197, 0.228]<1.0x10-300
AnthropometryImpd. of leg ROthersGenotype-only modelR20.079[0.068, 0.090]3.8x10-142
AnthropometryImpd. of leg ROthersFull model (covariates and genotypes)R20.282[0.265, 0.299]<1.0x10-300
AnthropometryImpd. of leg Lwhite BritishCovariate-only modelR20.181[0.176, 0.186]<1.0x10-300
AnthropometryImpd. of leg Lwhite BritishGenotype-only modelR20.111[0.107, 0.116]<1.0x10-300
AnthropometryImpd. of leg Lwhite BritishFull model (covariates and genotypes)R20.291[0.286, 0.297]<1.0x10-300
AnthropometryImpd. of leg LNon-British whiteCovariate-only modelR20.182[0.156, 0.207]1.4x10-125
AnthropometryImpd. of leg LNon-British whiteGenotype-only modelR20.102[0.081, 0.123]1.8x10-68
AnthropometryImpd. of leg LNon-British whiteFull model (covariates and genotypes)R20.286[0.259, 0.314]6.3x10-210
AnthropometryImpd. of leg LSouth AsianCovariate-only modelR20.117[0.086, 0.147]4.2x10-41
AnthropometryImpd. of leg LSouth AsianGenotype-only modelR20.085[0.058, 0.112]4.7x10-30
AnthropometryImpd. of leg LSouth AsianFull model (covariates and genotypes)R20.200[0.163, 0.236]2.7x10-72
AnthropometryImpd. of leg LAfricanCovariate-only modelR20.050[0.026, 0.074]1.0x10-14
AnthropometryImpd. of leg LAfricanGenotype-only modelR20.022[0.005, 0.038]4.7x10-07
AnthropometryImpd. of leg LAfricanFull model (covariates and genotypes)R20.072[0.044, 0.100]1.1x10-20
AnthropometryImpd. of leg LOthersCovariate-only modelR20.204[0.188, 0.220]<1.0x10-300
AnthropometryImpd. of leg LOthersGenotype-only modelR20.083[0.071, 0.094]5.9x10-149
AnthropometryImpd. of leg LOthersFull model (covariates and genotypes)R20.278[0.262, 0.295]<1.0x10-300
AnthropometryImpd. of arm Rwhite BritishCovariate-only modelR20.522[0.517, 0.527]<1.0x10-300
AnthropometryImpd. of arm Rwhite BritishGenotype-only modelR20.056[0.053, 0.059]<1.0x10-300
AnthropometryImpd. of arm Rwhite BritishFull model (covariates and genotypes)R20.577[0.572, 0.582]<1.0x10-300
AnthropometryImpd. of arm RNon-British whiteCovariate-only modelR20.531[0.506, 0.556]<1.0x10-300
AnthropometryImpd. of arm RNon-British whiteGenotype-only modelR20.058[0.042, 0.075]6.2x10-39
AnthropometryImpd. of arm RNon-British whiteFull model (covariates and genotypes)R20.586[0.563, 0.609]<1.0x10-300
AnthropometryImpd. of arm RSouth AsianCovariate-only modelR20.480[0.444, 0.517]7.5x10-209
AnthropometryImpd. of arm RSouth AsianGenotype-only modelR20.038[0.019, 0.057]7.0x10-14
AnthropometryImpd. of arm RSouth AsianFull model (covariates and genotypes)R20.522[0.487, 0.557]2.4x10-235
AnthropometryImpd. of arm RAfricanCovariate-only modelR20.352[0.308, 0.395]1.3x10-111
AnthropometryImpd. of arm RAfricanGenotype-only modelR20.022[0.006, 0.038]3.9x10-07
AnthropometryImpd. of arm RAfricanFull model (covariates and genotypes)R20.369[0.326, 0.412]2.1x10-118
AnthropometryImpd. of arm ROthersCovariate-only modelR20.535[0.520, 0.550]<1.0x10-300
AnthropometryImpd. of arm ROthersGenotype-only modelR20.044[0.035, 0.053]3.0x10-78
AnthropometryImpd. of arm ROthersFull model (covariates and genotypes)R20.576[0.562, 0.590]<1.0x10-300
AnthropometryImpd. of arm Lwhite BritishCovariate-only modelR20.529[0.523, 0.534]<1.0x10-300
AnthropometryImpd. of arm Lwhite BritishGenotype-only modelR20.059[0.056, 0.063]<1.0x10-300
AnthropometryImpd. of arm Lwhite BritishFull model (covariates and genotypes)R20.587[0.582, 0.591]<1.0x10-300
AnthropometryImpd. of arm LNon-British whiteCovariate-only modelR20.528[0.503, 0.553]<1.0x10-300
AnthropometryImpd. of arm LNon-British whiteGenotype-only modelR20.058[0.042, 0.075]5.3x10-39
AnthropometryImpd. of arm LNon-British whiteFull model (covariates and genotypes)R20.582[0.559, 0.605]<1.0x10-300
AnthropometryImpd. of arm LSouth AsianCovariate-only modelR20.474[0.437, 0.510]1.1x10-204
AnthropometryImpd. of arm LSouth AsianGenotype-only modelR20.049[0.027, 0.070]1.7x10-17
AnthropometryImpd. of arm LSouth AsianFull model (covariates and genotypes)R20.521[0.486, 0.556]1.3x10-234
AnthropometryImpd. of arm LAfricanCovariate-only modelR20.373[0.330, 0.416]2.5x10-120
AnthropometryImpd. of arm LAfricanGenotype-only modelR20.021[0.005, 0.037]7.1x10-07
AnthropometryImpd. of arm LAfricanFull model (covariates and genotypes)R20.390[0.347, 0.433]3.7x10-127
AnthropometryImpd. of arm LOthersCovariate-only modelR20.533[0.518, 0.548]<1.0x10-300
AnthropometryImpd. of arm LOthersGenotype-only modelR20.043[0.034, 0.051]3.7x10-76
AnthropometryImpd. of arm LOthersFull model (covariates and genotypes)R20.575[0.561, 0.589]<1.0x10-300
AnthropometryLeg fat % Rwhite BritishCovariate-only modelR20.740[0.737, 0.744]<1.0x10-300
AnthropometryLeg fat % Rwhite BritishGenotype-only modelR20.025[0.022, 0.027]<1.0x10-300
AnthropometryLeg fat % Rwhite BritishFull model (covariates and genotypes)R20.767[0.763, 0.770]<1.0x10-300
AnthropometryLeg fat % RNon-British whiteCovariate-only modelR20.722[0.704, 0.739]<1.0x10-300
AnthropometryLeg fat % RNon-British whiteGenotype-only modelR20.021[0.011, 0.032]6.7x10-15
AnthropometryLeg fat % RNon-British whiteFull model (covariates and genotypes)R20.753[0.737, 0.768]<1.0x10-300
AnthropometryLeg fat % RSouth AsianCovariate-only modelR20.789[0.770, 0.808]<1.0x10-300
AnthropometryLeg fat % RSouth AsianGenotype-only modelR20.014[0.002, 0.026]5.8x10-06
AnthropometryLeg fat % RSouth AsianFull model (covariates and genotypes)R20.800[0.782, 0.818]<1.0x10-300
AnthropometryLeg fat % RAfricanCovariate-only modelR20.800[0.780, 0.820]<1.0x10-300
AnthropometryLeg fat % RAfricanGenotype-only modelR20.006[-0.003, 0.014]8.6x10-03
AnthropometryLeg fat % RAfricanFull model (covariates and genotypes)R20.795[0.774, 0.815]<1.0x10-300
AnthropometryLeg fat % ROthersCovariate-only modelR20.728[0.718, 0.738]<1.0x10-300
AnthropometryLeg fat % ROthersGenotype-only modelR20.021[0.015, 0.027]1.1x10-37
AnthropometryLeg fat % ROthersFull model (covariates and genotypes)R20.746[0.736, 0.755]<1.0x10-300
AnthropometryLeg fat mass Rwhite BritishCovariate-only modelR20.321[0.315, 0.327]<1.0x10-300
AnthropometryLeg fat mass Rwhite BritishGenotype-only modelR20.065[0.061, 0.068]<1.0x10-300
AnthropometryLeg fat mass Rwhite BritishFull model (covariates and genotypes)R20.386[0.380, 0.392]<1.0x10-300
AnthropometryLeg fat mass RNon-British whiteCovariate-only modelR20.290[0.262, 0.317]1.3x10-212
AnthropometryLeg fat mass RNon-British whiteGenotype-only modelR20.060[0.043, 0.077]5.7x10-40
AnthropometryLeg fat mass RNon-British whiteFull model (covariates and genotypes)R20.360[0.332, 0.388]1.3x10-276
AnthropometryLeg fat mass RSouth AsianCovariate-only modelR20.430[0.392, 0.468]8.8x10-180
AnthropometryLeg fat mass RSouth AsianGenotype-only modelR20.053[0.031, 0.075]7.1x10-19
AnthropometryLeg fat mass RSouth AsianFull model (covariates and genotypes)R20.469[0.432, 0.505]1.1x10-201
AnthropometryLeg fat mass RAfricanCovariate-only modelR20.444[0.402, 0.485]1.7x10-150
AnthropometryLeg fat mass RAfricanGenotype-only modelR20.008[-0.002, 0.017]2.9x10-03
AnthropometryLeg fat mass RAfricanFull model (covariates and genotypes)R20.418[0.376, 0.460]4.2x10-139
AnthropometryLeg fat mass ROthersCovariate-only modelR20.322[0.305, 0.339]<1.0x10-300
AnthropometryLeg fat mass ROthersGenotype-only modelR20.064[0.054, 0.075]1.5x10-115
AnthropometryLeg fat mass ROthersFull model (covariates and genotypes)R20.371[0.354, 0.388]<1.0x10-300
AnthropometryLeg fat-free mass Rwhite BritishCovariate-only modelR20.649[0.644, 0.653]<1.0x10-300
AnthropometryLeg fat-free mass Rwhite BritishGenotype-only modelR20.054[0.050, 0.057]<1.0x10-300
AnthropometryLeg fat-free mass Rwhite BritishFull model (covariates and genotypes)R20.702[0.699, 0.706]<1.0x10-300
AnthropometryLeg fat-free mass RNon-British whiteCovariate-only modelR20.654[0.633, 0.674]<1.0x10-300
AnthropometryLeg fat-free mass RNon-British whiteGenotype-only modelR20.059[0.042, 0.076]2.1x10-39
AnthropometryLeg fat-free mass RNon-British whiteFull model (covariates and genotypes)R20.710[0.692, 0.728]<1.0x10-300
AnthropometryLeg fat-free mass RSouth AsianCovariate-only modelR20.609[0.578, 0.639]3.5x10-298
AnthropometryLeg fat-free mass RSouth AsianGenotype-only modelR20.024[0.009, 0.040]2.0x10-09
AnthropometryLeg fat-free mass RSouth AsianFull model (covariates and genotypes)R20.646[0.617, 0.675]<1.0x10-300
AnthropometryLeg fat-free mass RAfricanCovariate-only modelR20.521[0.482, 0.560]3.7x10-188
AnthropometryLeg fat-free mass RAfricanGenotype-only modelR20.006[-0.003, 0.015]7.7x10-03
AnthropometryLeg fat-free mass RAfricanFull model (covariates and genotypes)R20.518[0.479, 0.557]1.1x10-186
AnthropometryLeg fat-free mass ROthersCovariate-only modelR20.667[0.655, 0.679]<1.0x10-300
AnthropometryLeg fat-free mass ROthersGenotype-only modelR20.036[0.028, 0.044]3.0x10-64
AnthropometryLeg fat-free mass ROthersFull model (covariates and genotypes)R20.704[0.693, 0.715]<1.0x10-300
AnthropometryLeg fat % Lwhite BritishCovariate-only modelR20.763[0.760, 0.766]<1.0x10-300
AnthropometryLeg fat % Lwhite BritishGenotype-only modelR20.023[0.020, 0.025]<1.0x10-300
AnthropometryLeg fat % Lwhite BritishFull model (covariates and genotypes)R20.787[0.784, 0.790]<1.0x10-300
AnthropometryLeg fat % LNon-British whiteCovariate-only modelR20.746[0.730, 0.762]<1.0x10-300
AnthropometryLeg fat % LNon-British whiteGenotype-only modelR20.018[0.009, 0.028]3.7x10-13
AnthropometryLeg fat % LNon-British whiteFull model (covariates and genotypes)R20.774[0.760, 0.789]<1.0x10-300
AnthropometryLeg fat % LSouth AsianCovariate-only modelR20.822[0.806, 0.838]<1.0x10-300
AnthropometryLeg fat % LSouth AsianGenotype-only modelR20.017[0.004, 0.030]5.3x10-07
AnthropometryLeg fat % LSouth AsianFull model (covariates and genotypes)R20.835[0.819, 0.850]<1.0x10-300
AnthropometryLeg fat % LAfricanCovariate-only modelR20.814[0.795, 0.833]<1.0x10-300
AnthropometryLeg fat % LAfricanGenotype-only modelR20.005[-0.003, 0.012]2.0x10-02
AnthropometryLeg fat % LAfricanFull model (covariates and genotypes)R20.811[0.792, 0.830]<1.0x10-300
AnthropometryLeg fat % LOthersCovariate-only modelR20.753[0.744, 0.762]<1.0x10-300
AnthropometryLeg fat % LOthersGenotype-only modelR20.018[0.012, 0.024]1.2x10-32
AnthropometryLeg fat % LOthersFull model (covariates and genotypes)R20.770[0.761, 0.779]<1.0x10-300
AnthropometryLeg fat mass Lwhite BritishCovariate-only modelR20.334[0.328, 0.339]<1.0x10-300
AnthropometryLeg fat mass Lwhite BritishGenotype-only modelR20.063[0.060, 0.067]<1.0x10-300
AnthropometryLeg fat mass Lwhite BritishFull model (covariates and genotypes)R20.397[0.392, 0.403]<1.0x10-300
AnthropometryLeg fat mass LNon-British whiteCovariate-only modelR20.304[0.276, 0.332]7.3x10-225
AnthropometryLeg fat mass LNon-British whiteGenotype-only modelR20.058[0.041, 0.074]1.3x10-38
AnthropometryLeg fat mass LNon-British whiteFull model (covariates and genotypes)R20.372[0.345, 0.400]5.6x10-289
AnthropometryLeg fat mass LSouth AsianCovariate-only modelR20.456[0.418, 0.493]4.0x10-194
AnthropometryLeg fat mass LSouth AsianGenotype-only modelR20.054[0.031, 0.076]3.1x10-19
AnthropometryLeg fat mass LSouth AsianFull model (covariates and genotypes)R20.493[0.456, 0.529]2.8x10-216
AnthropometryLeg fat mass LAfricanCovariate-only modelR20.451[0.409, 0.492]1.3x10-153
AnthropometryLeg fat mass LAfricanGenotype-only modelR20.008[-0.002, 0.018]2.5x10-03
AnthropometryLeg fat mass LAfricanFull model (covariates and genotypes)R20.428[0.386, 0.470]1.7x10-143
AnthropometryLeg fat mass LOthersCovariate-only modelR20.334[0.317, 0.351]<1.0x10-300
AnthropometryLeg fat mass LOthersGenotype-only modelR20.062[0.052, 0.072]3.9x10-111
AnthropometryLeg fat mass LOthersFull model (covariates and genotypes)R20.382[0.365, 0.399]<1.0x10-300
AnthropometryLeg fat-free mass Lwhite BritishCovariate-only modelR20.643[0.639, 0.648]<1.0x10-300
AnthropometryLeg fat-free mass Lwhite BritishGenotype-only modelR20.054[0.051, 0.057]<1.0x10-300
AnthropometryLeg fat-free mass Lwhite BritishFull model (covariates and genotypes)R20.697[0.693, 0.701]<1.0x10-300
AnthropometryLeg fat-free mass LNon-British whiteCovariate-only modelR20.644[0.623, 0.664]<1.0x10-300
AnthropometryLeg fat-free mass LNon-British whiteGenotype-only modelR20.060[0.043, 0.076]7.7x10-40
AnthropometryLeg fat-free mass LNon-British whiteFull model (covariates and genotypes)R20.701[0.683, 0.719]<1.0x10-300
AnthropometryLeg fat-free mass LSouth AsianCovariate-only modelR20.615[0.584, 0.646]2.3x10-303
AnthropometryLeg fat-free mass LSouth AsianGenotype-only modelR20.026[0.010, 0.041]8.4x10-10
AnthropometryLeg fat-free mass LSouth AsianFull model (covariates and genotypes)R20.656[0.627, 0.684]<1.0x10-300
AnthropometryLeg fat-free mass LAfricanCovariate-only modelR20.506[0.466, 0.545]2.7x10-180
AnthropometryLeg fat-free mass LAfricanGenotype-only modelR20.006[-0.003, 0.014]1.0x10-02
AnthropometryLeg fat-free mass LAfricanFull model (covariates and genotypes)R20.504[0.465, 0.544]1.2x10-179
AnthropometryLeg fat-free mass LOthersCovariate-only modelR20.660[0.648, 0.672]<1.0x10-300
AnthropometryLeg fat-free mass LOthersGenotype-only modelR20.039[0.031, 0.047]1.1x10-69
AnthropometryLeg fat-free mass LOthersFull model (covariates and genotypes)R20.699[0.688, 0.710]<1.0x10-300
AnthropometryArm fat % Rwhite BritishCovariate-only modelR20.462[0.457, 0.468]<1.0x10-300
AnthropometryArm fat % Rwhite BritishGenotype-only modelR20.051[0.048, 0.055]<1.0x10-300
AnthropometryArm fat % Rwhite BritishFull model (covariates and genotypes)R20.514[0.509, 0.520]<1.0x10-300
AnthropometryArm fat % RNon-British whiteCovariate-only modelR20.426[0.399, 0.454]<1.0x10-300
AnthropometryArm fat % RNon-British whiteGenotype-only modelR20.050[0.034, 0.065]3.4x10-33
AnthropometryArm fat % RNon-British whiteFull model (covariates and genotypes)R20.482[0.456, 0.508]<1.0x10-300
AnthropometryArm fat % RSouth AsianCovariate-only modelR20.634[0.604, 0.663]1.9x10-308
AnthropometryArm fat % RSouth AsianGenotype-only modelR20.033[0.015, 0.050]4.0x10-12
AnthropometryArm fat % RSouth AsianFull model (covariates and genotypes)R20.649[0.621, 0.678]<1.0x10-300
AnthropometryArm fat % RAfricanCovariate-only modelR20.636[0.603, 0.668]1.5x10-257
AnthropometryArm fat % RAfricanGenotype-only modelR20.010[-0.001, 0.021]6.7x10-04
AnthropometryArm fat % RAfricanFull model (covariates and genotypes)R20.618[0.584, 0.651]2.6x10-245
AnthropometryArm fat % ROthersCovariate-only modelR20.441[0.424, 0.457]<1.0x10-300
AnthropometryArm fat % ROthersGenotype-only modelR20.050[0.041, 0.059]2.9x10-89
AnthropometryArm fat % ROthersFull model (covariates and genotypes)R20.482[0.466, 0.498]<1.0x10-300
AnthropometryArm fat mass Rwhite BritishCovariate-only modelR20.064[0.060, 0.068]<1.0x10-300
AnthropometryArm fat mass Rwhite BritishGenotype-only modelR20.086[0.082, 0.090]<1.0x10-300
AnthropometryArm fat mass Rwhite BritishFull model (covariates and genotypes)R20.149[0.144, 0.154]<1.0x10-300
AnthropometryArm fat mass RNon-British whiteCovariate-only modelR20.041[0.027, 0.055]1.4x10-27
AnthropometryArm fat mass RNon-British whiteGenotype-only modelR20.082[0.063, 0.101]1.4x10-54
AnthropometryArm fat mass RNon-British whiteFull model (covariates and genotypes)R20.124[0.101, 0.146]1.7x10-83
AnthropometryArm fat mass RSouth AsianCovariate-only modelR20.150[0.116, 0.183]4.0x10-53
AnthropometryArm fat mass RSouth AsianGenotype-only modelR20.074[0.048, 0.099]4.9x10-26
AnthropometryArm fat mass RSouth AsianFull model (covariates and genotypes)R20.198[0.162, 0.234]1.0x10-71
AnthropometryArm fat mass RAfricanCovariate-only modelR20.190[0.151, 0.230]2.6x10-55
AnthropometryArm fat mass RAfricanGenotype-only modelR20.008[-0.002, 0.019]1.6x10-03
AnthropometryArm fat mass RAfricanFull model (covariates and genotypes)R20.134[0.098, 0.170]2.7x10-38
AnthropometryArm fat mass ROthersCovariate-only modelR20.078[0.066, 0.089]1.6x10-139
AnthropometryArm fat mass ROthersGenotype-only modelR20.080[0.068, 0.091]2.1x10-143
AnthropometryArm fat mass ROthersFull model (covariates and genotypes)R20.146[0.131, 0.160]4.6x10-270
AnthropometryArm fat-free mass Rwhite BritishCovariate-only modelR20.721[0.717, 0.724]<1.0x10-300
AnthropometryArm fat-free mass Rwhite BritishGenotype-only modelR20.042[0.039, 0.045]<1.0x10-300
AnthropometryArm fat-free mass Rwhite BritishFull model (covariates and genotypes)R20.763[0.760, 0.766]<1.0x10-300
AnthropometryArm fat-free mass RNon-British whiteCovariate-only modelR20.716[0.699, 0.734]<1.0x10-300
AnthropometryArm fat-free mass RNon-British whiteGenotype-only modelR20.055[0.039, 0.071]5.9x10-37
AnthropometryArm fat-free mass RNon-British whiteFull model (covariates and genotypes)R20.763[0.748, 0.778]<1.0x10-300
AnthropometryArm fat-free mass RSouth AsianCovariate-only modelR20.689[0.663, 0.715]<1.0x10-300
AnthropometryArm fat-free mass RSouth AsianGenotype-only modelR20.026[0.010, 0.042]7.4x10-10
AnthropometryArm fat-free mass RSouth AsianFull model (covariates and genotypes)R20.725[0.701, 0.749]<1.0x10-300
AnthropometryArm fat-free mass RAfricanCovariate-only modelR20.642[0.609, 0.674]1.3x10-261
AnthropometryArm fat-free mass RAfricanGenotype-only modelR20.009[-0.001, 0.020]9.7x10-04
AnthropometryArm fat-free mass RAfricanFull model (covariates and genotypes)R20.644[0.612, 0.676]2.2x10-263
AnthropometryArm fat-free mass ROthersCovariate-only modelR20.730[0.720, 0.741]<1.0x10-300
AnthropometryArm fat-free mass ROthersGenotype-only modelR20.032[0.025, 0.040]6.8x10-58
AnthropometryArm fat-free mass ROthersFull model (covariates and genotypes)R20.761[0.752, 0.770]<1.0x10-300
AnthropometryArm fat % Lwhite BritishCovariate-only modelR20.465[0.460, 0.471]<1.0x10-300
AnthropometryArm fat % Lwhite BritishGenotype-only modelR20.052[0.049, 0.056]<1.0x10-300
AnthropometryArm fat % Lwhite BritishFull model (covariates and genotypes)R20.519[0.513, 0.524]<1.0x10-300
AnthropometryArm fat % LNon-British whiteCovariate-only modelR20.428[0.400, 0.455]<1.0x10-300
AnthropometryArm fat % LNon-British whiteGenotype-only modelR20.048[0.033, 0.063]3.8x10-32
AnthropometryArm fat % LNon-British whiteFull model (covariates and genotypes)R20.483[0.457, 0.510]<1.0x10-300
AnthropometryArm fat % LSouth AsianCovariate-only modelR20.604[0.573, 0.636]6.1x10-295
AnthropometryArm fat % LSouth AsianGenotype-only modelR20.038[0.019, 0.057]7.8x10-14
AnthropometryArm fat % LSouth AsianFull model (covariates and genotypes)R20.624[0.594, 0.654]1.9x10-308
AnthropometryArm fat % LAfricanCovariate-only modelR20.623[0.590, 0.656]8.3x10-249
AnthropometryArm fat % LAfricanGenotype-only modelR20.010[-0.001, 0.021]7.7x10-04
AnthropometryArm fat % LAfricanFull model (covariates and genotypes)R20.606[0.572, 0.641]6.6x10-238
AnthropometryArm fat % LOthersCovariate-only modelR20.437[0.421, 0.453]<1.0x10-300
AnthropometryArm fat % LOthersGenotype-only modelR20.051[0.042, 0.060]2.1x10-91
AnthropometryArm fat % LOthersFull model (covariates and genotypes)R20.480[0.465, 0.496]<1.0x10-300
AnthropometryArm fat mass Lwhite BritishCovariate-only modelR20.062[0.059, 0.066]<1.0x10-300
AnthropometryArm fat mass Lwhite BritishGenotype-only modelR20.084[0.080, 0.088]<1.0x10-300
AnthropometryArm fat mass Lwhite BritishFull model (covariates and genotypes)R20.144[0.139, 0.149]<1.0x10-300
AnthropometryArm fat mass LNon-British whiteCovariate-only modelR20.040[0.026, 0.054]4.4x10-27
AnthropometryArm fat mass LNon-British whiteGenotype-only modelR20.078[0.059, 0.097]6.0x10-52
AnthropometryArm fat mass LNon-British whiteFull model (covariates and genotypes)R20.120[0.097, 0.142]2.0x10-80
AnthropometryArm fat mass LSouth AsianCovariate-only modelR20.139[0.107, 0.172]2.9x10-49
AnthropometryArm fat mass LSouth AsianGenotype-only modelR20.070[0.045, 0.095]8.6x10-25
AnthropometryArm fat mass LSouth AsianFull model (covariates and genotypes)R20.187[0.151, 0.222]3.5x10-67
AnthropometryArm fat mass LAfricanCovariate-only modelR20.181[0.142, 0.220]1.7x10-52
AnthropometryArm fat mass LAfricanGenotype-only modelR20.007[-0.002, 0.016]4.2x10-03
AnthropometryArm fat mass LAfricanFull model (covariates and genotypes)R20.124[0.090, 0.159]1.7x10-35
AnthropometryArm fat mass LOthersCovariate-only modelR20.074[0.063, 0.085]4.1x10-133
AnthropometryArm fat mass LOthersGenotype-only modelR20.077[0.066, 0.089]3.6x10-139
AnthropometryArm fat mass LOthersFull model (covariates and genotypes)R20.140[0.126, 0.154]9.2x10-259
AnthropometryArm fat-free mass Lwhite BritishCovariate-only modelR20.692[0.688, 0.696]<1.0x10-300
AnthropometryArm fat-free mass Lwhite BritishGenotype-only modelR20.046[0.043, 0.049]<1.0x10-300
AnthropometryArm fat-free mass Lwhite BritishFull model (covariates and genotypes)R20.738[0.735, 0.742]<1.0x10-300
AnthropometryArm fat-free mass LNon-British whiteCovariate-only modelR20.690[0.671, 0.708]<1.0x10-300
AnthropometryArm fat-free mass LNon-British whiteGenotype-only modelR20.059[0.043, 0.076]1.1x10-39
AnthropometryArm fat-free mass LNon-British whiteFull model (covariates and genotypes)R20.740[0.724, 0.757]<1.0x10-300
AnthropometryArm fat-free mass LSouth AsianCovariate-only modelR20.630[0.600, 0.660]1.9x10-308
AnthropometryArm fat-free mass LSouth AsianGenotype-only modelR20.036[0.017, 0.054]4.0x10-13
AnthropometryArm fat-free mass LSouth AsianFull model (covariates and genotypes)R20.673[0.646, 0.700]<1.0x10-300
AnthropometryArm fat-free mass LAfricanCovariate-only modelR20.582[0.546, 0.618]1.7x10-222
AnthropometryArm fat-free mass LAfricanGenotype-only modelR20.007[-0.002, 0.017]3.3x10-03
AnthropometryArm fat-free mass LAfricanFull model (covariates and genotypes)R20.583[0.547, 0.619]3.6x10-223
AnthropometryArm fat-free mass LOthersCovariate-only modelR20.701[0.690, 0.712]<1.0x10-300
AnthropometryArm fat-free mass LOthersGenotype-only modelR20.036[0.028, 0.044]8.7x10-64
AnthropometryArm fat-free mass LOthersFull model (covariates and genotypes)R20.735[0.726, 0.745]<1.0x10-300
AnthropometryTrunk fat %white BritishCovariate-only modelR20.193[0.188, 0.198]<1.0x10-300
AnthropometryTrunk fat %white BritishGenotype-only modelR20.080[0.076, 0.084]<1.0x10-300
AnthropometryTrunk fat %white BritishFull model (covariates and genotypes)R20.274[0.268, 0.280]<1.0x10-300
AnthropometryTrunk fat %Non-British whiteCovariate-only modelR20.162[0.137, 0.186]1.1x10-110
AnthropometryTrunk fat %Non-British whiteGenotype-only modelR20.091[0.071, 0.111]1.1x10-60
AnthropometryTrunk fat %Non-British whiteFull model (covariates and genotypes)R20.253[0.225, 0.280]1.5x10-181
AnthropometryTrunk fat %South AsianCovariate-only modelR20.257[0.219, 0.295]1.2x10-95
AnthropometryTrunk fat %South AsianGenotype-only modelR20.070[0.045, 0.095]9.8x10-25
AnthropometryTrunk fat %South AsianFull model (covariates and genotypes)R20.313[0.274, 0.352]1.3x10-120
AnthropometryTrunk fat %AfricanCovariate-only modelR20.356[0.312, 0.399]4.4x10-113
AnthropometryTrunk fat %AfricanGenotype-only modelR20.011[-0.001, 0.023]3.0x10-04
AnthropometryTrunk fat %AfricanFull model (covariates and genotypes)R20.323[0.280, 0.366]1.5x10-100
AnthropometryTrunk fat %OthersCovariate-only modelR20.174[0.159, 0.189]<1.0x10-300
AnthropometryTrunk fat %OthersGenotype-only modelR20.081[0.070, 0.093]3.8x10-146
AnthropometryTrunk fat %OthersFull model (covariates and genotypes)R20.237[0.221, 0.253]<1.0x10-300
AnthropometryTrunk fat masswhite BritishCovariate-only modelR20.013[0.011, 0.015]3.5x10-193
AnthropometryTrunk fat masswhite BritishGenotype-only modelR20.116[0.111, 0.120]<1.0x10-300
AnthropometryTrunk fat masswhite BritishFull model (covariates and genotypes)R20.128[0.123, 0.132]<1.0x10-300
AnthropometryTrunk fat massNon-British whiteCovariate-only modelR20.011[0.003, 0.018]2.4x10-08
AnthropometryTrunk fat massNon-British whiteGenotype-only modelR20.132[0.109, 0.155]1.5x10-89
AnthropometryTrunk fat massNon-British whiteFull model (covariates and genotypes)R20.139[0.116, 0.162]3.6x10-94
AnthropometryTrunk fat massSouth AsianCovariate-only modelR20.022[0.007, 0.036]1.7x10-08
AnthropometryTrunk fat massSouth AsianGenotype-only modelR20.114[0.084, 0.145]2.8x10-40
AnthropometryTrunk fat massSouth AsianFull model (covariates and genotypes)R20.128[0.097, 0.160]2.9x10-45
AnthropometryTrunk fat massAfricanCovariate-only modelR20.008[-0.002, 0.019]1.8x10-03
AnthropometryTrunk fat massAfricanGenotype-only modelR20.016[0.002, 0.030]1.4x10-05
AnthropometryTrunk fat massAfricanFull model (covariates and genotypes)R20.023[0.006, 0.040]1.9x10-07
AnthropometryTrunk fat massOthersCovariate-only modelR20.059[0.049, 0.069]1.9x10-105
AnthropometryTrunk fat massOthersGenotype-only modelR20.106[0.093, 0.118]3.5x10-192
AnthropometryTrunk fat massOthersFull model (covariates and genotypes)R20.146[0.132, 0.160]9.1x10-271
AnthropometryTrunk fat-free masswhite BritishCovariate-only modelR20.717[0.713, 0.720]<1.0x10-300
AnthropometryTrunk fat-free masswhite BritishGenotype-only modelR20.053[0.050, 0.057]<1.0x10-300
AnthropometryTrunk fat-free masswhite BritishFull model (covariates and genotypes)R20.770[0.767, 0.773]<1.0x10-300
AnthropometryTrunk fat-free massNon-British whiteCovariate-only modelR20.709[0.692, 0.727]<1.0x10-300
AnthropometryTrunk fat-free massNon-British whiteGenotype-only modelR20.070[0.052, 0.088]1.6x10-46
AnthropometryTrunk fat-free massNon-British whiteFull model (covariates and genotypes)R20.768[0.753, 0.783]<1.0x10-300
AnthropometryTrunk fat-free massSouth AsianCovariate-only modelR20.638[0.609, 0.668]1.9x10-308
AnthropometryTrunk fat-free massSouth AsianGenotype-only modelR20.029[0.012, 0.045]7.9x10-11
AnthropometryTrunk fat-free massSouth AsianFull model (covariates and genotypes)R20.684[0.658, 0.711]<1.0x10-300
AnthropometryTrunk fat-free massAfricanCovariate-only modelR20.584[0.549, 0.620]6.0x10-224
AnthropometryTrunk fat-free massAfricanGenotype-only modelR20.009[-0.002, 0.019]1.5x10-03
AnthropometryTrunk fat-free massAfricanFull model (covariates and genotypes)R20.590[0.555, 0.625]2.2x10-227
AnthropometryTrunk fat-free massOthersCovariate-only modelR20.711[0.700, 0.722]<1.0x10-300
AnthropometryTrunk fat-free massOthersGenotype-only modelR20.041[0.032, 0.049]1.1x10-72
AnthropometryTrunk fat-free massOthersFull model (covariates and genotypes)R20.752[0.743, 0.762]<1.0x10-300
AnthropometryWaist circumferencewhite BritishCovariate-only modelR20.231[0.226, 0.237]<1.0x10-300
AnthropometryWaist circumferencewhite BritishGenotype-only modelR20.071[0.067, 0.075]<1.0x10-300
AnthropometryWaist circumferencewhite BritishFull model (covariates and genotypes)R20.299[0.294, 0.305]<1.0x10-300
AnthropometryWaist circumferenceNon-British whiteCovariate-only modelR20.236[0.209, 0.263]8.4x10-171
AnthropometryWaist circumferenceNon-British whiteGenotype-only modelR20.074[0.055, 0.092]7.1x10-50
AnthropometryWaist circumferenceNon-British whiteFull model (covariates and genotypes)R20.299[0.271, 0.326]3.6x10-224
AnthropometryWaist circumferenceSouth AsianCovariate-only modelR20.146[0.113, 0.179]1.9x10-52
AnthropometryWaist circumferenceSouth AsianGenotype-only modelR20.067[0.043, 0.091]5.6x10-24
AnthropometryWaist circumferenceSouth AsianFull model (covariates and genotypes)R20.211[0.175, 0.248]8.3x10-78
AnthropometryWaist circumferenceAfricanCovariate-only modelR20.018[0.003, 0.033]3.4x10-06
AnthropometryWaist circumferenceAfricanGenotype-only modelR20.016[0.002, 0.031]8.8x10-06
AnthropometryWaist circumferenceAfricanFull model (covariates and genotypes)R20.031[0.012, 0.050]8.7x10-10
AnthropometryWaist circumferenceOthersCovariate-only modelR20.244[0.227, 0.260]<1.0x10-300
AnthropometryWaist circumferenceOthersGenotype-only modelR20.051[0.041, 0.060]3.2x10-92
AnthropometryWaist circumferenceOthersFull model (covariates and genotypes)R20.289[0.272, 0.306]<1.0x10-300
AnthropometryHip circumferencewhite BritishCovariate-only modelR20.005[0.004, 0.006]1.1x10-74
AnthropometryHip circumferencewhite BritishGenotype-only modelR20.103[0.098, 0.107]<1.0x10-300
AnthropometryHip circumferencewhite BritishFull model (covariates and genotypes)R20.107[0.102, 0.111]<1.0x10-300
AnthropometryHip circumferenceNon-British whiteCovariate-only modelR20.001[-0.001, 0.003]1.0x10-01
AnthropometryHip circumferenceNon-British whiteGenotype-only modelR20.105[0.084, 0.126]1.9x10-71
AnthropometryHip circumferenceNon-British whiteFull model (covariates and genotypes)R20.103[0.082, 0.124]5.1x10-70
AnthropometryHip circumferenceSouth AsianCovariate-only modelR20.019[0.005, 0.032]1.4x10-07
AnthropometryHip circumferenceSouth AsianGenotype-only modelR20.085[0.058, 0.112]2.3x10-30
AnthropometryHip circumferenceSouth AsianFull model (covariates and genotypes)R20.098[0.070, 0.127]6.5x10-35
AnthropometryHip circumferenceAfricanCovariate-only modelR20.005[-0.003, 0.013]1.5x10-02
AnthropometryHip circumferenceAfricanGenotype-only modelR20.015[0.001, 0.028]2.5x10-05
AnthropometryHip circumferenceAfricanFull model (covariates and genotypes)R20.019[0.004, 0.034]2.0x10-06
AnthropometryHip circumferenceOthersCovariate-only modelR20.056[0.047, 0.066]1.8x10-102
AnthropometryHip circumferenceOthersGenotype-only modelR20.090[0.078, 0.102]7.5x10-166
AnthropometryHip circumferenceOthersFull model (covariates and genotypes)R20.130[0.116, 0.144]8.0x10-243
AnthropometryHeightwhite BritishCovariate-only modelR20.539[0.534, 0.544]<1.0x10-300
AnthropometryHeightwhite BritishGenotype-only modelR20.180[0.175, 0.186]<1.0x10-300
AnthropometryHeightwhite BritishFull model (covariates and genotypes)R20.719[0.715, 0.723]<1.0x10-300
AnthropometryHeightNon-British whiteCovariate-only modelR20.540[0.516, 0.565]<1.0x10-300
AnthropometryHeightNon-British whiteGenotype-only modelR20.210[0.184, 0.237]6.5x10-150
AnthropometryHeightNon-British whiteFull model (covariates and genotypes)R20.728[0.712, 0.745]<1.0x10-300
AnthropometryHeightSouth AsianCovariate-only modelR20.580[0.548, 0.613]8.2x10-275
AnthropometryHeightSouth AsianGenotype-only modelR20.083[0.056, 0.110]3.6x10-29
AnthropometryHeightSouth AsianFull model (covariates and genotypes)R20.669[0.642, 0.697]<1.0x10-300
AnthropometryHeightAfricanCovariate-only modelR20.489[0.449, 0.529]2.7x10-175
AnthropometryHeightAfricanGenotype-only modelR20.028[0.010, 0.046]6.8x10-09
AnthropometryHeightAfricanFull model (covariates and genotypes)R20.503[0.464, 0.543]2.6x10-182
AnthropometryHeightOthersCovariate-only modelR20.552[0.537, 0.566]<1.0x10-300
AnthropometryHeightOthersGenotype-only modelR20.151[0.137, 0.165]1.6x10-285
AnthropometryHeightOthersFull model (covariates and genotypes)R20.699[0.688, 0.710]<1.0x10-300
Blood assaysLeukocyte countwhite BritishCovariate-only modelR20.013[0.012, 0.015]7.7x10-196
Blood assaysLeukocyte countwhite BritishGenotype-only modelR20.076[0.073, 0.080]<1.0x10-300
Blood assaysLeukocyte countwhite BritishFull model (covariates and genotypes)R20.089[0.085, 0.093]<1.0x10-300
Blood assaysLeukocyte countNon-British whiteCovariate-only modelR20.018[0.008, 0.027]1.4x10-12
Blood assaysLeukocyte countNon-British whiteGenotype-only modelR20.076[0.058, 0.095]2.5x10-50
Blood assaysLeukocyte countNon-British whiteFull model (covariates and genotypes)R20.091[0.071, 0.111]3.2x10-60
Blood assaysLeukocyte countSouth AsianCovariate-only modelR20.007[-0.001, 0.016]1.4x10-03
Blood assaysLeukocyte countSouth AsianGenotype-only modelR20.090[0.062, 0.117]4.2x10-31
Blood assaysLeukocyte countSouth AsianFull model (covariates and genotypes)R20.094[0.066, 0.122]2.0x10-32
Blood assaysLeukocyte countAfricanCovariate-only modelR20.008[-0.002, 0.018]2.8x10-03
Blood assaysLeukocyte countAfricanGenotype-only modelR20.044[0.022, 0.067]5.4x10-13
Blood assaysLeukocyte countAfricanFull model (covariates and genotypes)R20.051[0.027, 0.075]9.2x10-15
Blood assaysLeukocyte countOthersCovariate-only modelR20.028[0.021, 0.035]2.4x10-49
Blood assaysLeukocyte countOthersGenotype-only modelR20.082[0.071, 0.094]6.8x10-147
Blood assaysLeukocyte countOthersFull model (covariates and genotypes)R20.098[0.086, 0.111]2.7x10-176
Blood assaysErythrocyte countwhite BritishCovariate-only modelR20.265[0.260, 0.271]<1.0x10-300
Blood assaysErythrocyte countwhite BritishGenotype-only modelR20.118[0.113, 0.122]<1.0x10-300
Blood assaysErythrocyte countwhite BritishFull model (covariates and genotypes)R20.382[0.376, 0.388]<1.0x10-300
Blood assaysErythrocyte countNon-British whiteCovariate-only modelR20.296[0.268, 0.324]1.2x10-216
Blood assaysErythrocyte countNon-British whiteGenotype-only modelR20.093[0.073, 0.113]1.7x10-61
Blood assaysErythrocyte countNon-British whiteFull model (covariates and genotypes)R20.389[0.362, 0.417]3.3x10-303
Blood assaysErythrocyte countSouth AsianCovariate-only modelR20.277[0.238, 0.315]1.1x10-102
Blood assaysErythrocyte countSouth AsianGenotype-only modelR20.075[0.049, 0.101]4.8x10-26
Blood assaysErythrocyte countSouth AsianFull model (covariates and genotypes)R20.353[0.314, 0.392]3.2x10-137
Blood assaysErythrocyte countAfricanCovariate-only modelR20.259[0.217, 0.302]3.7x10-77
Blood assaysErythrocyte countAfricanGenotype-only modelR20.041[0.020, 0.063]2.8x10-12
Blood assaysErythrocyte countAfricanFull model (covariates and genotypes)R20.295[0.252, 0.338]1.9x10-89
Blood assaysErythrocyte countOthersCovariate-only modelR20.311[0.294, 0.327]<1.0x10-300
Blood assaysErythrocyte countOthersGenotype-only modelR20.101[0.089, 0.114]3.5x10-182
Blood assaysErythrocyte countOthersFull model (covariates and genotypes)R20.388[0.371, 0.405]<1.0x10-300
Blood assaysHemoglobin conc.white BritishCovariate-only modelR20.369[0.363, 0.375]<1.0x10-300
Blood assaysHemoglobin conc.white BritishGenotype-only modelR20.068[0.065, 0.072]<1.0x10-300
Blood assaysHemoglobin conc.white BritishFull model (covariates and genotypes)R20.438[0.432, 0.443]<1.0x10-300
Blood assaysHemoglobin conc.Non-British whiteCovariate-only modelR20.399[0.371, 0.427]1.9x10-308
Blood assaysHemoglobin conc.Non-British whiteGenotype-only modelR20.063[0.046, 0.080]1.7x10-41
Blood assaysHemoglobin conc.Non-British whiteFull model (covariates and genotypes)R20.465[0.438, 0.491]<1.0x10-300
Blood assaysHemoglobin conc.South AsianCovariate-only modelR20.397[0.359, 0.436]2.5x10-159
Blood assaysHemoglobin conc.South AsianGenotype-only modelR20.029[0.012, 0.045]1.1x10-10
Blood assaysHemoglobin conc.South AsianFull model (covariates and genotypes)R20.430[0.392, 0.468]9.7x10-177
Blood assaysHemoglobin conc.AfricanCovariate-only modelR20.394[0.352, 0.437]1.2x10-127
Blood assaysHemoglobin conc.AfricanGenotype-only modelR20.018[0.003, 0.032]6.2x10-06
Blood assaysHemoglobin conc.AfricanFull model (covariates and genotypes)R20.401[0.359, 0.444]2.0x10-130
Blood assaysHemoglobin conc.OthersCovariate-only modelR20.393[0.376, 0.410]<1.0x10-300
Blood assaysHemoglobin conc.OthersGenotype-only modelR20.048[0.039, 0.057]3.0x10-85
Blood assaysHemoglobin conc.OthersFull model (covariates and genotypes)R20.435[0.419, 0.452]<1.0x10-300
Blood assaysHematocrit %white BritishCovariate-only modelR20.333[0.327, 0.339]<1.0x10-300
Blood assaysHematocrit %white BritishGenotype-only modelR20.067[0.064, 0.071]<1.0x10-300
Blood assaysHematocrit %white BritishFull model (covariates and genotypes)R20.400[0.394, 0.405]<1.0x10-300
Blood assaysHematocrit %Non-British whiteCovariate-only modelR20.367[0.339, 0.395]1.3x10-281
Blood assaysHematocrit %Non-British whiteGenotype-only modelR20.058[0.041, 0.074]2.3x10-38
Blood assaysHematocrit %Non-British whiteFull model (covariates and genotypes)R20.426[0.398, 0.453]<1.0x10-300
Blood assaysHematocrit %South AsianCovariate-only modelR20.390[0.351, 0.429]1.4x10-155
Blood assaysHematocrit %South AsianGenotype-only modelR20.033[0.015, 0.051]3.9x10-12
Blood assaysHematocrit %South AsianFull model (covariates and genotypes)R20.426[0.388, 0.464]2.5x10-174
Blood assaysHematocrit %AfricanCovariate-only modelR20.406[0.363, 0.448]2.3x10-132
Blood assaysHematocrit %AfricanGenotype-only modelR20.016[0.002, 0.030]1.5x10-05
Blood assaysHematocrit %AfricanFull model (covariates and genotypes)R20.413[0.370, 0.455]2.4x10-135
Blood assaysHematocrit %OthersCovariate-only modelR20.359[0.342, 0.375]<1.0x10-300
Blood assaysHematocrit %OthersGenotype-only modelR20.049[0.039, 0.058]6.3x10-86
Blood assaysHematocrit %OthersFull model (covariates and genotypes)R20.404[0.387, 0.420]<1.0x10-300
Blood assaysMean corpuscular vol.white BritishCovariate-only modelR20.018[0.016, 0.020]4.4x10-264
Blood assaysMean corpuscular vol.white BritishGenotype-only modelR20.200[0.194, 0.205]<1.0x10-300
Blood assaysMean corpuscular vol.white BritishFull model (covariates and genotypes)R20.215[0.209, 0.220]<1.0x10-300
Blood assaysMean corpuscular vol.Non-British whiteCovariate-only modelR20.026[0.015, 0.038]4.4x10-18
Blood assaysMean corpuscular vol.Non-British whiteGenotype-only modelR20.196[0.170, 0.222]1.4x10-135
Blood assaysMean corpuscular vol.Non-British whiteFull model (covariates and genotypes)R20.219[0.192, 0.245]9.7x10-153
Blood assaysMean corpuscular vol.South AsianCovariate-only modelR20.037[0.018, 0.056]2.3x10-13
Blood assaysMean corpuscular vol.South AsianGenotype-only modelR20.101[0.072, 0.130]6.5x10-35
Blood assaysMean corpuscular vol.South AsianFull model (covariates and genotypes)R20.131[0.099, 0.163]1.3x10-45
Blood assaysMean corpuscular vol.AfricanCovariate-only modelR20.023[0.006, 0.039]2.6x10-07
Blood assaysMean corpuscular vol.AfricanGenotype-only modelR20.058[0.033, 0.084]9.6x10-17
Blood assaysMean corpuscular vol.AfricanFull model (covariates and genotypes)R20.075[0.047, 0.104]2.3x10-21
Blood assaysMean corpuscular vol.OthersCovariate-only modelR20.076[0.065, 0.087]2.3x10-135
Blood assaysMean corpuscular vol.OthersGenotype-only modelR20.141[0.127, 0.155]7.8x10-258
Blood assaysMean corpuscular vol.OthersFull model (covariates and genotypes)R20.188[0.173, 0.204]<1.0x10-300
Blood assaysMean corpuscular hemoglobinwhite BritishCovariate-only modelR20.020[0.018, 0.022]4.7x10-292
Blood assaysMean corpuscular hemoglobinwhite BritishGenotype-only modelR20.167[0.162, 0.172]<1.0x10-300
Blood assaysMean corpuscular hemoglobinwhite BritishFull model (covariates and genotypes)R20.184[0.179, 0.190]<1.0x10-300
Blood assaysMean corpuscular hemoglobinNon-British whiteCovariate-only modelR20.028[0.016, 0.040]4.5x10-19
Blood assaysMean corpuscular hemoglobinNon-British whiteGenotype-only modelR20.183[0.158, 0.209]1.2x10-125
Blood assaysMean corpuscular hemoglobinNon-British whiteFull model (covariates and genotypes)R20.205[0.179, 0.231]4.3x10-142
Blood assaysMean corpuscular hemoglobinSouth AsianCovariate-only modelR20.034[0.016, 0.052]2.1x10-12
Blood assaysMean corpuscular hemoglobinSouth AsianGenotype-only modelR20.086[0.059, 0.114]6.3x10-30
Blood assaysMean corpuscular hemoglobinSouth AsianFull model (covariates and genotypes)R20.116[0.085, 0.146]3.5x10-40
Blood assaysMean corpuscular hemoglobinAfricanCovariate-only modelR20.022[0.005, 0.038]5.3x10-07
Blood assaysMean corpuscular hemoglobinAfricanGenotype-only modelR20.055[0.030, 0.079]8.5x10-16
Blood assaysMean corpuscular hemoglobinAfricanFull model (covariates and genotypes)R20.072[0.044, 0.100]1.9x10-20
Blood assaysMean corpuscular hemoglobinOthersCovariate-only modelR20.083[0.071, 0.094]6.2x10-147
Blood assaysMean corpuscular hemoglobinOthersGenotype-only modelR20.128[0.114, 0.141]7.3x10-232
Blood assaysMean corpuscular hemoglobinOthersFull model (covariates and genotypes)R20.174[0.159, 0.189]1.9x10-308
Blood assaysMean corpuscular hemoglobin conc.white BritishCovariate-only modelR20.015[0.013, 0.017]6.6x10-218
Blood assaysMean corpuscular hemoglobin conc.white BritishGenotype-only modelR20.025[0.023, 0.028]<1.0x10-300
Blood assaysMean corpuscular hemoglobin conc.white BritishFull model (covariates and genotypes)R20.040[0.037, 0.043]<1.0x10-300
Blood assaysMean corpuscular hemoglobin conc.Non-British whiteCovariate-only modelR20.020[0.010, 0.029]1.0x10-13
Blood assaysMean corpuscular hemoglobin conc.Non-British whiteGenotype-only modelR20.032[0.019, 0.044]1.4x10-21
Blood assaysMean corpuscular hemoglobin conc.Non-British whiteFull model (covariates and genotypes)R20.049[0.033, 0.064]2.8x10-32
Blood assaysMean corpuscular hemoglobin conc.South AsianCovariate-only modelR20.009[-0.000, 0.019]2.6x10-04
Blood assaysMean corpuscular hemoglobin conc.South AsianGenotype-only modelR20.017[0.004, 0.030]6.3x10-07
Blood assaysMean corpuscular hemoglobin conc.South AsianFull model (covariates and genotypes)R20.025[0.010, 0.041]1.6x10-09
Blood assaysMean corpuscular hemoglobin conc.AfricanCovariate-only modelR20.009[-0.002, 0.019]1.4x10-03
Blood assaysMean corpuscular hemoglobin conc.AfricanGenotype-only modelR20.009[-0.002, 0.019]1.6x10-03
Blood assaysMean corpuscular hemoglobin conc.AfricanFull model (covariates and genotypes)R20.016[0.002, 0.030]1.5x10-05
Blood assaysMean corpuscular hemoglobin conc.OthersCovariate-only modelR20.035[0.027, 0.043]1.5x10-62
Blood assaysMean corpuscular hemoglobin conc.OthersGenotype-only modelR20.024[0.017, 0.030]1.6x10-42
Blood assaysMean corpuscular hemoglobin conc.OthersFull model (covariates and genotypes)R20.050[0.040, 0.059]1.5x10-87
Blood assaysErythrocyte dist. widthwhite BritishCovariate-only modelR20.013[0.011, 0.014]1.4x10-186
Blood assaysErythrocyte dist. widthwhite BritishGenotype-only modelR20.079[0.076, 0.083]<1.0x10-300
Blood assaysErythrocyte dist. widthwhite BritishFull model (covariates and genotypes)R20.092[0.088, 0.096]<1.0x10-300
Blood assaysErythrocyte dist. widthNon-British whiteCovariate-only modelR20.021[0.011, 0.032]6.8x10-15
Blood assaysErythrocyte dist. widthNon-British whiteGenotype-only modelR20.087[0.068, 0.107]7.1x10-58
Blood assaysErythrocyte dist. widthNon-British whiteFull model (covariates and genotypes)R20.106[0.085, 0.127]1.6x10-70
Blood assaysErythrocyte dist. widthSouth AsianCovariate-only modelR20.015[0.003, 0.027]4.1x10-06
Blood assaysErythrocyte dist. widthSouth AsianGenotype-only modelR20.052[0.030, 0.075]1.6x10-18
Blood assaysErythrocyte dist. widthSouth AsianFull model (covariates and genotypes)R20.066[0.042, 0.091]3.7x10-23
Blood assaysErythrocyte dist. widthAfricanCovariate-only modelR20.008[-0.002, 0.018]2.2x10-03
Blood assaysErythrocyte dist. widthAfricanGenotype-only modelR20.018[0.003, 0.033]4.5x10-06
Blood assaysErythrocyte dist. widthAfricanFull model (covariates and genotypes)R20.026[0.009, 0.044]2.9x10-08
Blood assaysErythrocyte dist. widthOthersCovariate-only modelR20.027[0.020, 0.034]5.9x10-48
Blood assaysErythrocyte dist. widthOthersGenotype-only modelR20.067[0.057, 0.078]1.4x10-119
Blood assaysErythrocyte dist. widthOthersFull model (covariates and genotypes)R20.088[0.076, 0.100]1.6x10-156
Blood assaysPlatelet countwhite BritishCovariate-only modelR20.060[0.057, 0.064]<1.0x10-300
Blood assaysPlatelet countwhite BritishGenotype-only modelR20.209[0.204, 0.215]<1.0x10-300
Blood assaysPlatelet countwhite BritishFull model (covariates and genotypes)R20.268[0.263, 0.274]<1.0x10-300
Blood assaysPlatelet countNon-British whiteCovariate-only modelR20.045[0.031, 0.060]3.5x10-30
Blood assaysPlatelet countNon-British whiteGenotype-only modelR20.225[0.198, 0.251]1.6x10-157
Blood assaysPlatelet countNon-British whiteFull model (covariates and genotypes)R20.266[0.238, 0.293]1.4x10-190
Blood assaysPlatelet countSouth AsianCovariate-only modelR20.085[0.058, 0.112]2.3x10-29
Blood assaysPlatelet countSouth AsianGenotype-only modelR20.156[0.122, 0.190]1.2x10-54
Blood assaysPlatelet countSouth AsianFull model (covariates and genotypes)R20.235[0.197, 0.272]3.7x10-85
Blood assaysPlatelet countAfricanCovariate-only modelR20.090[0.060, 0.121]1.7x10-25
Blood assaysPlatelet countAfricanGenotype-only modelR20.067[0.040, 0.094]4.9x10-19
Blood assaysPlatelet countAfricanFull model (covariates and genotypes)R20.139[0.103, 0.175]1.7x10-39
Blood assaysPlatelet countOthersCovariate-only modelR20.063[0.053, 0.073]2.7x10-111
Blood assaysPlatelet countOthersGenotype-only modelR20.193[0.178, 0.209]<1.0x10-300
Blood assaysPlatelet countOthersFull model (covariates and genotypes)R20.249[0.232, 0.265]<1.0x10-300
Blood assaysPlatelet critwhite BritishCovariate-only modelR20.089[0.085, 0.093]<1.0x10-300
Blood assaysPlatelet critwhite BritishGenotype-only modelR20.163[0.158, 0.168]<1.0x10-300
Blood assaysPlatelet critwhite BritishFull model (covariates and genotypes)R20.252[0.246, 0.257]<1.0x10-300
Blood assaysPlatelet critNon-British whiteCovariate-only modelR20.075[0.057, 0.094]1.1x10-49
Blood assaysPlatelet critNon-British whiteGenotype-only modelR20.177[0.152, 0.202]7.1x10-121
Blood assaysPlatelet critNon-British whiteFull model (covariates and genotypes)R20.248[0.221, 0.276]1.9x10-176
Blood assaysPlatelet critSouth AsianCovariate-only modelR20.139[0.106, 0.171]2.1x10-48
Blood assaysPlatelet critSouth AsianGenotype-only modelR20.120[0.089, 0.151]1.2x10-41
Blood assaysPlatelet critSouth AsianFull model (covariates and genotypes)R20.248[0.210, 0.286]1.8x10-90
Blood assaysPlatelet critAfricanCovariate-only modelR20.123[0.089, 0.158]9.0x10-35
Blood assaysPlatelet critAfricanGenotype-only modelR20.044[0.021, 0.066]6.3x10-13
Blood assaysPlatelet critAfricanFull model (covariates and genotypes)R20.152[0.115, 0.189]2.8x10-43
Blood assaysPlatelet critOthersCovariate-only modelR20.095[0.083, 0.107]1.4x10-169
Blood assaysPlatelet critOthersGenotype-only modelR20.138[0.124, 0.152]1.7x10-252
Blood assaysPlatelet critOthersFull model (covariates and genotypes)R20.229[0.213, 0.245]<1.0x10-300
Blood assaysMean platelet vol.white BritishCovariate-only modelR20.003[0.002, 0.004]2.9x10-45
Blood assaysMean platelet vol.white BritishGenotype-only modelR20.358[0.353, 0.364]<1.0x10-300
Blood assaysMean platelet vol.white BritishFull model (covariates and genotypes)R20.361[0.355, 0.367]<1.0x10-300
Blood assaysMean platelet vol.Non-British whiteCovariate-only modelR20.008[0.002, 0.015]1.1x10-06
Blood assaysMean platelet vol.Non-British whiteGenotype-only modelR20.359[0.331, 0.387]3.4x10-274
Blood assaysMean platelet vol.Non-British whiteFull model (covariates and genotypes)R20.364[0.336, 0.392]1.2x10-278
Blood assaysMean platelet vol.South AsianCovariate-only modelR20.003[-0.003, 0.008]5.0x10-02
Blood assaysMean platelet vol.South AsianGenotype-only modelR20.232[0.194, 0.269]5.4x10-84
Blood assaysMean platelet vol.South AsianFull model (covariates and genotypes)R20.232[0.195, 0.270]4.5x10-84
Blood assaysMean platelet vol.AfricanCovariate-only modelR20.001[-0.002, 0.004]3.3x10-01
Blood assaysMean platelet vol.AfricanGenotype-only modelR20.109[0.076, 0.142]6.3x10-31
Blood assaysMean platelet vol.AfricanFull model (covariates and genotypes)R20.110[0.077, 0.143]5.1x10-31
Blood assaysMean platelet vol.OthersCovariate-only modelR20.019[0.013, 0.025]2.3x10-34
Blood assaysMean platelet vol.OthersGenotype-only modelR20.315[0.299, 0.332]<1.0x10-300
Blood assaysMean platelet vol.OthersFull model (covariates and genotypes)R20.309[0.293, 0.326]<1.0x10-300
Blood assaysPlatelet dist. widthwhite BritishCovariate-only modelR20.022[0.019, 0.024]1.9x10-308
Blood assaysPlatelet dist. widthwhite BritishGenotype-only modelR20.209[0.203, 0.214]<1.0x10-300
Blood assaysPlatelet dist. widthwhite BritishFull model (covariates and genotypes)R20.231[0.226, 0.237]<1.0x10-300
Blood assaysPlatelet dist. widthNon-British whiteCovariate-only modelR20.010[0.003, 0.017]1.3x10-07
Blood assaysPlatelet dist. widthNon-British whiteGenotype-only modelR20.199[0.173, 0.225]1.8x10-137
Blood assaysPlatelet dist. widthNon-British whiteFull model (covariates and genotypes)R20.208[0.182, 0.234]1.8x10-144
Blood assaysPlatelet dist. widthSouth AsianCovariate-only modelR20.013[0.002, 0.025]1.2x10-05
Blood assaysPlatelet dist. widthSouth AsianGenotype-only modelR20.166[0.132, 0.201]1.8x10-58
Blood assaysPlatelet dist. widthSouth AsianFull model (covariates and genotypes)R20.184[0.148, 0.219]4.9x10-65
Blood assaysPlatelet dist. widthAfricanCovariate-only modelR20.032[0.013, 0.052]8.2x10-10
Blood assaysPlatelet dist. widthAfricanGenotype-only modelR20.066[0.039, 0.093]7.8x10-19
Blood assaysPlatelet dist. widthAfricanFull model (covariates and genotypes)R20.090[0.060, 0.121]1.7x10-25
Blood assaysPlatelet dist. widthOthersCovariate-only modelR20.045[0.037, 0.054]3.4x10-80
Blood assaysPlatelet dist. widthOthersGenotype-only modelR20.198[0.182, 0.214]<1.0x10-300
Blood assaysPlatelet dist. widthOthersFull model (covariates and genotypes)R20.224[0.208, 0.240]<1.0x10-300
Blood assaysLymphocyte countwhite BritishCovariate-only modelR20.006[0.004, 0.007]2.6x10-82
Blood assaysLymphocyte countwhite BritishGenotype-only modelR20.022[0.020, 0.024]1.9x10-308
Blood assaysLymphocyte countwhite BritishFull model (covariates and genotypes)R20.027[0.025, 0.030]<1.0x10-300
Blood assaysLymphocyte countNon-British whiteCovariate-only modelR20.007[0.001, 0.014]5.1x10-06
Blood assaysLymphocyte countNon-British whiteGenotype-only modelR20.027[0.015, 0.039]1.9x10-18
Blood assaysLymphocyte countNon-British whiteFull model (covariates and genotypes)R20.034[0.021, 0.047]8.8x10-23
Blood assaysLymphocyte countSouth AsianCovariate-only modelR20.020[0.006, 0.034]1.0x10-07
Blood assaysLymphocyte countSouth AsianGenotype-only modelR20.042[0.022, 0.062]4.1x10-15
Blood assaysLymphocyte countSouth AsianFull model (covariates and genotypes)R20.059[0.036, 0.082]1.3x10-20
Blood assaysLymphocyte countAfricanCovariate-only modelR20.024[0.007, 0.040]1.7x10-07
Blood assaysLymphocyte countAfricanGenotype-only modelR20.006[-0.003, 0.014]1.2x10-02
Blood assaysLymphocyte countAfricanFull model (covariates and genotypes)R20.019[0.004, 0.034]3.4x10-06
Blood assaysLymphocyte countOthersCovariate-only modelR20.021[0.015, 0.027]3.2x10-37
Blood assaysLymphocyte countOthersGenotype-only modelR20.029[0.022, 0.036]2.4x10-51
Blood assaysLymphocyte countOthersFull model (covariates and genotypes)R20.047[0.038, 0.056]9.4x10-83
Blood assaysMonocyte countwhite BritishCovariate-only modelR20.042[0.039, 0.045]<1.0x10-300
Blood assaysMonocyte countwhite BritishGenotype-only modelR20.082[0.078, 0.086]<1.0x10-300
Blood assaysMonocyte countwhite BritishFull model (covariates and genotypes)R20.124[0.120, 0.129]<1.0x10-300
Blood assaysMonocyte countNon-British whiteCovariate-only modelR20.057[0.040, 0.073]2.1x10-37
Blood assaysMonocyte countNon-British whiteGenotype-only modelR20.090[0.070, 0.110]2.1x10-59
Blood assaysMonocyte countNon-British whiteFull model (covariates and genotypes)R20.145[0.121, 0.169]1.2x10-97
Blood assaysMonocyte countSouth AsianCovariate-only modelR20.044[0.024, 0.065]8.6x10-16
Blood assaysMonocyte countSouth AsianGenotype-only modelR20.070[0.045, 0.095]2.2x10-24
Blood assaysMonocyte countSouth AsianFull model (covariates and genotypes)R20.113[0.082, 0.143]7.8x10-39
Blood assaysMonocyte countAfricanCovariate-only modelR20.005[-0.003, 0.013]1.3x10-02
Blood assaysMonocyte countAfricanGenotype-only modelR20.033[0.014, 0.053]3.9x10-10
Blood assaysMonocyte countAfricanFull model (covariates and genotypes)R20.033[0.014, 0.053]4.2x10-10
Blood assaysMonocyte countOthersCovariate-only modelR20.043[0.034, 0.051]3.0x10-75
Blood assaysMonocyte countOthersGenotype-only modelR20.079[0.068, 0.091]6.1x10-141
Blood assaysMonocyte countOthersFull model (covariates and genotypes)R20.111[0.098, 0.124]6.0x10-199
Blood assaysNeutrophil countwhite BritishCovariate-only modelR20.019[0.017, 0.021]2.1x10-278
Blood assaysNeutrophil countwhite BritishGenotype-only modelR20.090[0.086, 0.094]<1.0x10-300
Blood assaysNeutrophil countwhite BritishFull model (covariates and genotypes)R20.109[0.104, 0.113]<1.0x10-300
Blood assaysNeutrophil countNon-British whiteCovariate-only modelR20.022[0.011, 0.032]4.9x10-15
Blood assaysNeutrophil countNon-British whiteGenotype-only modelR20.093[0.072, 0.113]2.8x10-61
Blood assaysNeutrophil countNon-British whiteFull model (covariates and genotypes)R20.113[0.092, 0.135]2.5x10-75
Blood assaysNeutrophil countSouth AsianCovariate-only modelR20.011[0.000, 0.021]8.4x10-05
Blood assaysNeutrophil countSouth AsianGenotype-only modelR20.080[0.054, 0.106]1.0x10-27
Blood assaysNeutrophil countSouth AsianFull model (covariates and genotypes)R20.089[0.061, 0.116]1.4x10-30
Blood assaysNeutrophil countAfricanCovariate-only modelR20.016[0.002, 0.031]1.3x10-05
Blood assaysNeutrophil countAfricanGenotype-only modelR20.057[0.032, 0.082]2.4x10-16
Blood assaysNeutrophil countAfricanFull model (covariates and genotypes)R20.070[0.042, 0.098]6.3x10-20
Blood assaysNeutrophil countOthersCovariate-only modelR20.037[0.029, 0.045]1.2x10-64
Blood assaysNeutrophil countOthersGenotype-only modelR20.096[0.084, 0.109]2.9x10-172
Blood assaysNeutrophil countOthersFull model (covariates and genotypes)R20.109[0.096, 0.122]6.0x10-196
Blood assaysEosinophil countwhite BritishCovariate-only modelR20.009[0.007, 0.010]9.8x10-129
Blood assaysEosinophil countwhite BritishGenotype-only modelR20.093[0.089, 0.097]<1.0x10-300
Blood assaysEosinophil countwhite BritishFull model (covariates and genotypes)R20.101[0.097, 0.106]<1.0x10-300
Blood assaysEosinophil countNon-British whiteCovariate-only modelR20.013[0.005, 0.021]2.4x10-09
Blood assaysEosinophil countNon-British whiteGenotype-only modelR20.072[0.054, 0.090]1.8x10-47
Blood assaysEosinophil countNon-British whiteFull model (covariates and genotypes)R20.084[0.065, 0.104]1.4x10-55
Blood assaysEosinophil countSouth AsianCovariate-only modelR20.005[-0.002, 0.013]5.8x10-03
Blood assaysEosinophil countSouth AsianGenotype-only modelR20.048[0.027, 0.069]5.6x10-17
Blood assaysEosinophil countSouth AsianFull model (covariates and genotypes)R20.053[0.031, 0.075]1.2x10-18
Blood assaysEosinophil countAfricanCovariate-only modelR20.010[-0.001, 0.021]7.1x10-04
Blood assaysEosinophil countAfricanGenotype-only modelR20.007[-0.002, 0.016]6.1x10-03
Blood assaysEosinophil countAfricanFull model (covariates and genotypes)R20.013[0.000, 0.026]9.9x10-05
Blood assaysEosinophil countOthersCovariate-only modelR20.028[0.021, 0.035]3.5x10-50
Blood assaysEosinophil countOthersGenotype-only modelR20.069[0.058, 0.080]3.7x10-122
Blood assaysEosinophil countOthersFull model (covariates and genotypes)R20.093[0.081, 0.105]2.0x10-165
Blood assaysBasophil countwhite BritishCovariate-only modelR20.004[0.003, 0.005]1.1x10-65
Blood assaysBasophil countwhite BritishGenotype-only modelR20.015[0.013, 0.017]1.2x10-220
Blood assaysBasophil countwhite BritishFull model (covariates and genotypes)R20.019[0.017, 0.021]2.0x10-282
Blood assaysBasophil countNon-British whiteCovariate-only modelR20.004[-0.001, 0.009]7.8x10-04
Blood assaysBasophil countNon-British whiteGenotype-only modelR20.018[0.009, 0.028]4.6x10-13
Blood assaysBasophil countNon-British whiteFull model (covariates and genotypes)R20.022[0.011, 0.032]4.5x10-15
Blood assaysBasophil countSouth AsianCovariate-only modelR20.002[-0.002, 0.006]1.1x10-01
Blood assaysBasophil countSouth AsianGenotype-only modelR20.006[-0.002, 0.013]5.0x10-03
Blood assaysBasophil countSouth AsianFull model (covariates and genotypes)R20.007[-0.001, 0.015]1.8x10-03
Blood assaysBasophil countAfricanCovariate-only modelR20.005[-0.003, 0.013]1.3x10-02
Blood assaysBasophil countAfricanGenotype-only modelR20.004[-0.003, 0.012]2.3x10-02
Blood assaysBasophil countAfricanFull model (covariates and genotypes)R20.010[-0.001, 0.021]7.6x10-04
Blood assaysBasophil countOthersCovariate-only modelR20.009[0.005, 0.013]5.9x10-17
Blood assaysBasophil countOthersGenotype-only modelR20.014[0.009, 0.019]1.0x10-24
Blood assaysBasophil countOthersFull model (covariates and genotypes)R20.021[0.015, 0.028]4.7x10-38
Blood assaysLymphocyte %white BritishCovariate-only modelR20.033[0.031, 0.036]<1.0x10-300
Blood assaysLymphocyte %white BritishGenotype-only modelR20.090[0.086, 0.094]<1.0x10-300
Blood assaysLymphocyte %white BritishFull model (covariates and genotypes)R20.123[0.119, 0.128]<1.0x10-300
Blood assaysLymphocyte %Non-British whiteCovariate-only modelR20.029[0.017, 0.041]1.7x10-19
Blood assaysLymphocyte %Non-British whiteGenotype-only modelR20.082[0.063, 0.101]4.4x10-54
Blood assaysLymphocyte %Non-British whiteFull model (covariates and genotypes)R20.112[0.090, 0.134]1.9x10-74
Blood assaysLymphocyte %South AsianCovariate-only modelR20.021[0.007, 0.036]3.4x10-08
Blood assaysLymphocyte %South AsianGenotype-only modelR20.054[0.031, 0.076]8.4x10-19
Blood assaysLymphocyte %South AsianFull model (covariates and genotypes)R20.074[0.049, 0.100]1.2x10-25
Blood assaysLymphocyte %AfricanCovariate-only modelR20.026[0.008, 0.044]3.9x10-08
Blood assaysLymphocyte %AfricanGenotype-only modelR20.047[0.024, 0.070]1.1x10-13
Blood assaysLymphocyte %AfricanFull model (covariates and genotypes)R20.069[0.041, 0.096]1.4x10-19
Blood assaysLymphocyte %OthersCovariate-only modelR20.074[0.063, 0.085]6.9x10-131
Blood assaysLymphocyte %OthersGenotype-only modelR20.111[0.098, 0.124]2.1x10-200
Blood assaysLymphocyte %OthersFull model (covariates and genotypes)R20.153[0.139, 0.168]1.1x10-281
Blood assaysMonocyte %white BritishCovariate-only modelR20.043[0.040, 0.046]<1.0x10-300
Blood assaysMonocyte %white BritishGenotype-only modelR20.085[0.081, 0.090]<1.0x10-300
Blood assaysMonocyte %white BritishFull model (covariates and genotypes)R20.128[0.123, 0.133]<1.0x10-300
Blood assaysMonocyte %Non-British whiteCovariate-only modelR20.040[0.026, 0.054]1.0x10-26
Blood assaysMonocyte %Non-British whiteGenotype-only modelR20.085[0.066, 0.105]1.7x10-56
Blood assaysMonocyte %Non-British whiteFull model (covariates and genotypes)R20.122[0.100, 0.145]1.6x10-81
Blood assaysMonocyte %South AsianCovariate-only modelR20.083[0.056, 0.110]1.1x10-28
Blood assaysMonocyte %South AsianGenotype-only modelR20.071[0.046, 0.096]1.7x10-24
Blood assaysMonocyte %South AsianFull model (covariates and genotypes)R20.152[0.119, 0.186]4.2x10-53
Blood assaysMonocyte %AfricanCovariate-only modelR20.016[0.002, 0.029]2.1x10-05
Blood assaysMonocyte %AfricanGenotype-only modelR20.018[0.003, 0.032]6.3x10-06
Blood assaysMonocyte %AfricanFull model (covariates and genotypes)R20.034[0.014, 0.054]3.3x10-10
Blood assaysMonocyte %OthersCovariate-only modelR20.039[0.031, 0.048]2.7x10-69
Blood assaysMonocyte %OthersGenotype-only modelR20.056[0.046, 0.066]3.2x10-99
Blood assaysMonocyte %OthersFull model (covariates and genotypes)R20.088[0.076, 0.100]2.7x10-157
Blood assaysNeutrophil %white BritishCovariate-only modelR20.012[0.011, 0.014]1.1x10-179
Blood assaysNeutrophil %white BritishGenotype-only modelR20.083[0.079, 0.087]<1.0x10-300
Blood assaysNeutrophil %white BritishFull model (covariates and genotypes)R20.095[0.091, 0.099]<1.0x10-300
Blood assaysNeutrophil %Non-British whiteCovariate-only modelR20.008[0.002, 0.015]1.1x10-06
Blood assaysNeutrophil %Non-British whiteGenotype-only modelR20.081[0.062, 0.100]1.8x10-53
Blood assaysNeutrophil %Non-British whiteFull model (covariates and genotypes)R20.090[0.070, 0.110]2.5x10-59
Blood assaysNeutrophil %South AsianCovariate-only modelR20.012[0.001, 0.024]2.4x10-05
Blood assaysNeutrophil %South AsianGenotype-only modelR20.047[0.026, 0.068]1.1x10-16
Blood assaysNeutrophil %South AsianFull model (covariates and genotypes)R20.060[0.037, 0.083]6.3x10-21
Blood assaysNeutrophil %AfricanCovariate-only modelR20.031[0.012, 0.050]2.2x10-09
Blood assaysNeutrophil %AfricanGenotype-only modelR20.043[0.020, 0.065]1.5x10-12
Blood assaysNeutrophil %AfricanFull model (covariates and genotypes)R20.067[0.040, 0.094]4.2x10-19
Blood assaysNeutrophil %OthersCovariate-only modelR20.055[0.045, 0.064]3.2x10-96
Blood assaysNeutrophil %OthersGenotype-only modelR20.093[0.081, 0.106]6.0x10-167
Blood assaysNeutrophil %OthersFull model (covariates and genotypes)R20.121[0.108, 0.135]6.3x10-219
Blood assaysEosinophil %white BritishCovariate-only modelR20.008[0.007, 0.009]3.1x10-116
Blood assaysEosinophil %white BritishGenotype-only modelR20.095[0.090, 0.099]<1.0x10-300
Blood assaysEosinophil %white BritishFull model (covariates and genotypes)R20.102[0.098, 0.107]<1.0x10-300
Blood assaysEosinophil %Non-British whiteCovariate-only modelR20.010[0.003, 0.018]7.4x10-08
Blood assaysEosinophil %Non-British whiteGenotype-only modelR20.059[0.042, 0.076]5.8x10-39
Blood assaysEosinophil %Non-British whiteFull model (covariates and genotypes)R20.069[0.052, 0.087]7.9x10-46
Blood assaysEosinophil %South AsianCovariate-only modelR20.011[0.001, 0.022]5.5x10-05
Blood assaysEosinophil %South AsianGenotype-only modelR20.065[0.041, 0.090]9.1x10-23
Blood assaysEosinophil %South AsianFull model (covariates and genotypes)R20.076[0.050, 0.102]3.3x10-26
Blood assaysEosinophil %AfricanCovariate-only modelR20.020[0.005, 0.036]1.1x10-06
Blood assaysEosinophil %AfricanGenotype-only modelR20.006[-0.003, 0.014]9.9x10-03
Blood assaysEosinophil %AfricanFull model (covariates and genotypes)R20.017[0.003, 0.031]9.2x10-06
Blood assaysEosinophil %OthersCovariate-only modelR20.022[0.016, 0.028]2.1x10-39
Blood assaysEosinophil %OthersGenotype-only modelR20.076[0.065, 0.087]1.3x10-134
Blood assaysEosinophil %OthersFull model (covariates and genotypes)R20.097[0.084, 0.109]7.1x10-173
Blood assaysBasophil %white BritishCovariate-only modelR20.002[0.002, 0.003]2.0x10-34
Blood assaysBasophil %white BritishGenotype-only modelR20.016[0.014, 0.018]5.2x10-229
Blood assaysBasophil %white BritishFull model (covariates and genotypes)R20.018[0.016, 0.020]9.2x10-258
Blood assaysBasophil %Non-British whiteCovariate-only modelR20.004[-0.001, 0.008]1.1x10-03
Blood assaysBasophil %Non-British whiteGenotype-only modelR20.018[0.008, 0.027]1.7x10-12
Blood assaysBasophil %Non-British whiteFull model (covariates and genotypes)R20.021[0.011, 0.031]1.3x10-14
Blood assaysBasophil %South AsianCovariate-only modelR20.000[-0.002, 0.002]4.4x10-01
Blood assaysBasophil %South AsianGenotype-only modelR20.005[-0.002, 0.012]9.4x10-03
Blood assaysBasophil %South AsianFull model (covariates and genotypes)R20.005[-0.002, 0.012]1.0x10-02
Blood assaysBasophil %AfricanCovariate-only modelR20.002[-0.003, 0.008]9.2x10-02
Blood assaysBasophil %AfricanGenotype-only modelR20.002[-0.003, 0.007]1.3x10-01
Blood assaysBasophil %AfricanFull model (covariates and genotypes)R20.004[-0.003, 0.012]2.5x10-02
Blood assaysBasophil %OthersCovariate-only modelR20.011[0.007, 0.016]9.3x10-21
Blood assaysBasophil %OthersGenotype-only modelR20.012[0.008, 0.017]6.4x10-23
Blood assaysBasophil %OthersFull model (covariates and genotypes)R20.023[0.016, 0.029]7.6x10-41
Blood assaysReticulocyte %white BritishCovariate-only modelR20.002[0.001, 0.002]4.8x10-23
Blood assaysReticulocyte %white BritishGenotype-only modelR20.028[0.026, 0.031]<1.0x10-300
Blood assaysReticulocyte %white BritishFull model (covariates and genotypes)R20.030[0.027, 0.032]<1.0x10-300
Blood assaysReticulocyte %Non-British whiteCovariate-only modelR20.005[0.000, 0.011]1.1x10-04
Blood assaysReticulocyte %Non-British whiteGenotype-only modelR20.069[0.051, 0.086]1.2x10-44
Blood assaysReticulocyte %Non-British whiteFull model (covariates and genotypes)R20.075[0.056, 0.093]1.4x10-48
Blood assaysReticulocyte %South AsianCovariate-only modelR20.010[0.000, 0.021]1.5x10-04
Blood assaysReticulocyte %South AsianGenotype-only modelR20.082[0.055, 0.109]1.1x10-27
Blood assaysReticulocyte %South AsianFull model (covariates and genotypes)R20.089[0.061, 0.117]5.5x10-30
Blood assaysReticulocyte %AfricanCovariate-only modelR20.000[-0.002, 0.003]4.7x10-01
Blood assaysReticulocyte %AfricanGenotype-only modelR20.016[0.002, 0.030]2.4x10-05
Blood assaysReticulocyte %AfricanFull model (covariates and genotypes)R20.012[0.000, 0.025]1.8x10-04
Blood assaysReticulocyte %OthersCovariate-only modelR20.007[0.003, 0.011]2.3x10-13
Blood assaysReticulocyte %OthersGenotype-only modelR20.036[0.028, 0.044]1.1x10-62
Blood assaysReticulocyte %OthersFull model (covariates and genotypes)R20.042[0.033, 0.050]8.9x10-72
Blood assaysReticulocyte countwhite BritishCovariate-only modelR20.013[0.011, 0.015]4.9x10-186
Blood assaysReticulocyte countwhite BritishGenotype-only modelR20.041[0.038, 0.044]<1.0x10-300
Blood assaysReticulocyte countwhite BritishFull model (covariates and genotypes)R20.054[0.050, 0.057]<1.0x10-300
Blood assaysReticulocyte countNon-British whiteCovariate-only modelR20.029[0.017, 0.041]1.4x10-19
Blood assaysReticulocyte countNon-British whiteGenotype-only modelR20.071[0.053, 0.089]3.9x10-46
Blood assaysReticulocyte countNon-British whiteFull model (covariates and genotypes)R20.101[0.081, 0.122]2.7x10-66
Blood assaysReticulocyte countSouth AsianCovariate-only modelR20.028[0.012, 0.045]2.8x10-10
Blood assaysReticulocyte countSouth AsianGenotype-only modelR20.071[0.046, 0.096]3.7x10-24
Blood assaysReticulocyte countSouth AsianFull model (covariates and genotypes)R20.097[0.069, 0.126]8.7x10-33
Blood assaysReticulocyte countAfricanCovariate-only modelR20.012[-0.000, 0.024]2.6x10-04
Blood assaysReticulocyte countAfricanGenotype-only modelR20.015[0.001, 0.028]4.8x10-05
Blood assaysReticulocyte countAfricanFull model (covariates and genotypes)R20.027[0.009, 0.045]2.9x10-08
Blood assaysReticulocyte countOthersCovariate-only modelR20.022[0.015, 0.028]6.9x10-38
Blood assaysReticulocyte countOthersGenotype-only modelR20.036[0.028, 0.043]1.5x10-61
Blood assaysReticulocyte countOthersFull model (covariates and genotypes)R20.055[0.045, 0.064]1.6x10-94
Blood assaysMean reticulocyte vol.white BritishCovariate-only modelR20.016[0.014, 0.018]3.6x10-225
Blood assaysMean reticulocyte vol.white BritishGenotype-only modelR20.146[0.141, 0.151]<1.0x10-300
Blood assaysMean reticulocyte vol.white BritishFull model (covariates and genotypes)R20.161[0.156, 0.166]<1.0x10-300
Blood assaysMean reticulocyte vol.Non-British whiteCovariate-only modelR20.029[0.017, 0.041]1.1x10-19
Blood assaysMean reticulocyte vol.Non-British whiteGenotype-only modelR20.144[0.120, 0.168]1.1x10-95
Blood assaysMean reticulocyte vol.Non-British whiteFull model (covariates and genotypes)R20.172[0.147, 0.197]1.2x10-115
Blood assaysMean reticulocyte vol.South AsianCovariate-only modelR20.034[0.016, 0.052]4.5x10-12
Blood assaysMean reticulocyte vol.South AsianGenotype-only modelR20.110[0.080, 0.140]3.5x10-37
Blood assaysMean reticulocyte vol.South AsianFull model (covariates and genotypes)R20.138[0.105, 0.170]1.1x10-46
Blood assaysMean reticulocyte vol.AfricanCovariate-only modelR20.006[-0.003, 0.014]1.1x10-02
Blood assaysMean reticulocyte vol.AfricanGenotype-only modelR20.033[0.014, 0.053]6.4x10-10
Blood assaysMean reticulocyte vol.AfricanFull model (covariates and genotypes)R20.039[0.018, 0.060]3.0x10-11
Blood assaysMean reticulocyte vol.OthersCovariate-only modelR20.036[0.028, 0.044]1.2x10-62
Blood assaysMean reticulocyte vol.OthersGenotype-only modelR20.130[0.117, 0.144]2.7x10-232
Blood assaysMean reticulocyte vol.OthersFull model (covariates and genotypes)R20.155[0.141, 0.170]2.8x10-279
Blood assaysMean sphered cell vol.white BritishCovariate-only modelR20.012[0.011, 0.014]2.7x10-175
Blood assaysMean sphered cell vol.white BritishGenotype-only modelR20.153[0.148, 0.158]<1.0x10-300
Blood assaysMean sphered cell vol.white BritishFull model (covariates and genotypes)R20.164[0.159, 0.169]<1.0x10-300
Blood assaysMean sphered cell vol.Non-British whiteCovariate-only modelR20.024[0.013, 0.035]2.1x10-16
Blood assaysMean sphered cell vol.Non-British whiteGenotype-only modelR20.155[0.131, 0.180]1.2x10-103
Blood assaysMean sphered cell vol.Non-British whiteFull model (covariates and genotypes)R20.179[0.154, 0.204]1.8x10-120
Blood assaysMean sphered cell vol.South AsianCovariate-only modelR20.017[0.004, 0.030]1.2x10-06
Blood assaysMean sphered cell vol.South AsianGenotype-only modelR20.103[0.074, 0.132]1.2x10-34
Blood assaysMean sphered cell vol.South AsianFull model (covariates and genotypes)R20.116[0.086, 0.147]3.7x10-39
Blood assaysMean sphered cell vol.AfricanCovariate-only modelR20.002[-0.003, 0.007]1.5x10-01
Blood assaysMean sphered cell vol.AfricanGenotype-only modelR20.033[0.013, 0.052]9.4x10-10
Blood assaysMean sphered cell vol.AfricanFull model (covariates and genotypes)R20.034[0.014, 0.054]5.7x10-10
Blood assaysMean sphered cell vol.OthersCovariate-only modelR20.039[0.030, 0.047]6.8x10-67
Blood assaysMean sphered cell vol.OthersGenotype-only modelR20.137[0.123, 0.151]6.6x10-245
Blood assaysMean sphered cell vol.OthersFull model (covariates and genotypes)R20.164[0.149, 0.178]7.3x10-296
Blood assaysImmature reticulocyte frac.white BritishCovariate-only modelR20.011[0.009, 0.013]1.6x10-157
Blood assaysImmature reticulocyte frac.white BritishGenotype-only modelR20.093[0.089, 0.097]<1.0x10-300
Blood assaysImmature reticulocyte frac.white BritishFull model (covariates and genotypes)R20.103[0.099, 0.108]<1.0x10-300
Blood assaysImmature reticulocyte frac.Non-British whiteCovariate-only modelR20.006[0.000, 0.012]4.6x10-05
Blood assaysImmature reticulocyte frac.Non-British whiteGenotype-only modelR20.094[0.074, 0.114]2.4x10-61
Blood assaysImmature reticulocyte frac.Non-British whiteFull model (covariates and genotypes)R20.098[0.077, 0.119]5.9x10-64
Blood assaysImmature reticulocyte frac.South AsianCovariate-only modelR20.010[0.000, 0.021]1.3x10-04
Blood assaysImmature reticulocyte frac.South AsianGenotype-only modelR20.054[0.032, 0.076]1.4x10-18
Blood assaysImmature reticulocyte frac.South AsianFull model (covariates and genotypes)R20.061[0.037, 0.084]9.3x10-21
Blood assaysImmature reticulocyte frac.AfricanCovariate-only modelR20.007[-0.002, 0.016]4.8x10-03
Blood assaysImmature reticulocyte frac.AfricanGenotype-only modelR20.040[0.018, 0.061]1.7x10-11
Blood assaysImmature reticulocyte frac.AfricanFull model (covariates and genotypes)R20.048[0.024, 0.071]1.4x10-13
Blood assaysImmature reticulocyte frac.OthersCovariate-only modelR20.029[0.022, 0.036]6.4x10-50
Blood assaysImmature reticulocyte frac.OthersGenotype-only modelR20.082[0.070, 0.093]1.4x10-142
Blood assaysImmature reticulocyte frac.OthersFull model (covariates and genotypes)R20.109[0.096, 0.122]4.8x10-192
Blood assaysHigh light scatter reticulocyte %white BritishCovariate-only modelR20.001[0.001, 0.002]4.9x10-19
Blood assaysHigh light scatter reticulocyte %white BritishGenotype-only modelR20.017[0.015, 0.019]4.0x10-246
Blood assaysHigh light scatter reticulocyte %white BritishFull model (covariates and genotypes)R20.018[0.016, 0.020]1.4x10-262
Blood assaysHigh light scatter reticulocyte %Non-British whiteCovariate-only modelR20.006[0.000, 0.012]4.3x10-05
Blood assaysHigh light scatter reticulocyte %Non-British whiteGenotype-only modelR20.099[0.078, 0.119]1.5x10-64
Blood assaysHigh light scatter reticulocyte %Non-British whiteFull model (covariates and genotypes)R20.105[0.083, 0.126]2.6x10-68
Blood assaysHigh light scatter reticulocyte %South AsianCovariate-only modelR20.016[0.003, 0.029]2.0x10-06
Blood assaysHigh light scatter reticulocyte %South AsianGenotype-only modelR20.088[0.060, 0.115]1.5x10-29
Blood assaysHigh light scatter reticulocyte %South AsianFull model (covariates and genotypes)R20.097[0.069, 0.126]8.1x10-33
Blood assaysHigh light scatter reticulocyte %AfricanCovariate-only modelR20.000[-0.002, 0.003]4.7x10-01
Blood assaysHigh light scatter reticulocyte %AfricanGenotype-only modelR20.031[0.012, 0.050]2.7x10-09
Blood assaysHigh light scatter reticulocyte %AfricanFull model (covariates and genotypes)R20.030[0.011, 0.049]5.3x10-09
Blood assaysHigh light scatter reticulocyte %OthersCovariate-only modelR20.017[0.012, 0.023]1.6x10-30
Blood assaysHigh light scatter reticulocyte %OthersGenotype-only modelR20.083[0.071, 0.094]1.7x10-144
Blood assaysHigh light scatter reticulocyte %OthersFull model (covariates and genotypes)R20.095[0.083, 0.107]5.0x10-166
Blood assaysHigh light scatter reticulocyte countwhite BritishCovariate-only modelR20.017[0.016, 0.019]3.9x10-250
Blood assaysHigh light scatter reticulocyte countwhite BritishGenotype-only modelR20.113[0.109, 0.118]<1.0x10-300
Blood assaysHigh light scatter reticulocyte countwhite BritishFull model (covariates and genotypes)R20.131[0.126, 0.135]<1.0x10-300
Blood assaysHigh light scatter reticulocyte countNon-British whiteCovariate-only modelR20.019[0.009, 0.029]4.0x10-13
Blood assaysHigh light scatter reticulocyte countNon-British whiteGenotype-only modelR20.122[0.099, 0.144]4.5x10-80
Blood assaysHigh light scatter reticulocyte countNon-British whiteFull model (covariates and genotypes)R20.141[0.118, 0.165]1.7x10-93
Blood assaysHigh light scatter reticulocyte countSouth AsianCovariate-only modelR20.026[0.010, 0.042]1.5x10-09
Blood assaysHigh light scatter reticulocyte countSouth AsianGenotype-only modelR20.091[0.063, 0.119]1.2x10-30
Blood assaysHigh light scatter reticulocyte countSouth AsianFull model (covariates and genotypes)R20.113[0.082, 0.143]6.1x10-38
Blood assaysHigh light scatter reticulocyte countAfricanCovariate-only modelR20.007[-0.002, 0.017]3.7x10-03
Blood assaysHigh light scatter reticulocyte countAfricanGenotype-only modelR20.040[0.019, 0.062]1.1x10-11
Blood assaysHigh light scatter reticulocyte countAfricanFull model (covariates and genotypes)R20.048[0.024, 0.071]1.3x10-13
Blood assaysHigh light scatter reticulocyte countOthersCovariate-only modelR20.040[0.031, 0.048]2.6x10-68
Blood assaysHigh light scatter reticulocyte countOthersGenotype-only modelR20.093[0.081, 0.106]1.6x10-163
Blood assaysHigh light scatter reticulocyte countOthersFull model (covariates and genotypes)R20.125[0.111, 0.138]3.2x10-221

The predictive performance (R2), its 95% confidence interval (CI), and statistical significance (P-value) are shown for each population in UK Biobank in the held-out test set. The "model" column indicates whether the predictive performance is from the covariate-terms alone (covariate-only model), PGS terms alone (Genotype-only model), or the full model containing both PGS and covariate terms. We used the following sets of covariates in our analysis: age, sex, age2, age*sex, Townsend deprivation index, and genotype PCs (PC1-PC18). Please refer to our publication for a more detailed description of the methods.


References